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췌장의 선방세포악성종양

Other Titles
 The Clinical Characteristics of Acinar Cell Carcinoma in the Pancreas 
Authors
 김혜운  ;  류제규  ;  최새별  ;  황호경  ;  김경식  ;  윤동섭  ;  이우정 
Citation
 Korean Journal of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지), Vol.13(1) : 54-59, 2009 
Journal Title
 Korean Journal of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지) 
ISSN
 1738-6349 
Issue Date
2009
Keywords
Pancreatic cancer ; Acinar cell carcinoma ; CA19-9 ; radical resection ; Adjuvant chemotherapy
Abstract
Acinar cell carcinoma (ACC) is a very rare type of pancreatic cancer that makes up less than 1%of all pancreatic cancers. The prognosis of ACC is very poor and the mean survival interval isonly 18-19 months. The only effective treatment is currently early radical resection.Materials and methods: To determine ACC`s clinical characteristics and the treatment efficacy,we conducted a retrospective chart review to study the clinical characteristics, laboratoryfindings, pathology and treatment responses of 10 ACC patients among 3042 pancreatic cancerpatients who were diagnosed in Severance Hospital and Kangnam Severance Hospital ofYonsei University, College of Medicine from 1988.01.01 to 2008.12.31.Results: The 10 ACC patients were 6 males and 4 females. The mean age of the 10 ACCpatients was 53.2 years. The most of the patients (7/10) complained the pain on the epigastricarea and there was no jaundice in 8 patients (80%). Unfortunately, regional or distantmetastases were founded in 8 patients (80%) at the time of the first diagnosis. The initial meanCA19-9 level was increased to 73.5 U/ml (range: 0.1~350.0 U/ml). Six of 10 patients underwentradical surgery and 4 of 10, including 1 with open and closure, were treated with conservativetreatment. The median survival interval was 22.4 months with operative treatment and 1.5months with conservative treatment. The median overall survival interval was 19.4 months. Themedian disease free survival was 17 months. The liver was the most common recurrent site (3cases).Conclusions: An early radical resection is currently the best and only treatment for ACC, but inrare cases, post-operative adjuvant chemotherapy shows hopeful results and so this requiresmore study.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Choi, Sae Byeol(최새별)
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103914
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