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Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer.

Authors
 Hye Won Chung  ;  Sang-Guk Lee  ;  Heejung Kim  ;  Duck Jin Hong  ;  Jae Bock Chung  ;  David Stroncek  ;  Jong-Baeck Lim 
Citation
 JOURNAL OF TRANSLATIONAL MEDICINE, Vol.7 : 38, 2009 
Journal Title
 JOURNAL OF TRANSLATIONAL MEDICINE 
Issue Date
2009
MeSH
Carcinoembryonic Antigen/blood ; Female ; HMGB1 Protein/blood* ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; ROC Curve ; Sensitivity and Specificity ; Stomach Neoplasms/blood* ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology* ; Survival Analysis
Keywords
Gastric Cancer ; Gastric Cancer Patient ; Early Gastric Cancer ; Advanced Gastric Cancer ; Intestinal Metaplasia
Abstract
BACKGROUND: High mobility group box-1 (HMGB1) is a newly recognized factor regulating cancer cell tumorigenesis, expansion and invasion. We investigated the correlation between the serum HMGB1 levels and the clinical and pathologic features of gastric cancer and evaluated the validity of HMGB1 as a potential biomarker for the early diagnosis of gastric cancer. METHODS: A total of 227 subjects were classified into 5 disease groups according to the 'gastritis-dysplasia-carcinoma' sequence of gastric carcinogenesis and their serum levels of HMGB1 were analyzed by an enzyme-linked immunosorbent assay (ELISA) method. Clinical parameters, International Union Against Cancer (UICC) TNM stage, cancer size, differentiation or lymphatic invasion, vascular or perineural invasion and prognosis were used as analysis variables. RESULTS: The serum HMGB1 levels were significantly different among disease groups (ANOVA, p < 0.05) and HMGB1 levels tended to increase according to the progression of gastric carcinogenesis. Serum HMGB1 levels were significantly associated with depth of invasion, lymph node metastasis, tumor size, and poor prognosis (p < 0.05). However, HMGB1 levels were not associated with patient gender or age, differentiation of tumor cells, or lymphatic, vascular and perineural invasion, or the existence of distant metastasis in advanced cancer (p > 0.05). The sensitivity and specificity of serum HMGB1 was 71% and 67% (cut-off value of 5 ng/ml) for the diagnosis of early gastric cancer, and 70% and 64% (cut-off value of 4 ng/ml) for the diagnosis of high-risk lesions, respectively. These values were greater than those for carcinoembryonic antigen (CEA) (30-40% of sensitivity). CONCLUSION: HMGB1 appears to be a useful serological biomarker for early diagnosis as well as evaluating the tumorigenesis, stage, and prognosis of gastric cancer.
Files in This Item:
T200901314.pdf Download
DOI
10.1186/1479-5876-7-38
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
Chung, Jae Bock(정재복)
Chung, Hye Won(정혜원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103903
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