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Variability in liver stiffness values from different intercostal spaces

 Seung Up Kim  ;  Ja Kyung Kim  ;  Jun Yong Park  ;  Sang Hoon Ahn  ;  Jung Min Lee  ;  Oidov Baatarkhuu  ;  Eun Hee Choi  ;  Kwang-Hyub Han  ;  Chae Yoon Chon  ;  Do Young Kim 
 LIVER INTERNATIONAL, Vol.29(5) : 760-766, 2009 
Journal Title
Issue Date
Adult ; Female ; Hepatitis B, Chronic/complications* ; Humans ; Korea ; Liver/diagnostic imaging* ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/etiology ; Logistic Models ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Ultrasonography
chronic hepatitis B ; cirrhosis ; FibroScan ® ; fibrosis ; hepatitis B virus ; intercostal space ; liver stiffness measurement ; transient elastography ; variability
AIM: To investigate the variability in liver stiffness measurement (LSM) values from the fifth, sixth and seventh intercostal space (ICS) and examine whether LSM better predicts significant fibrosis (F2-4) and cirrhosis when LSM is performed at the same site as liver biopsy (LB). METHODS: This study enrolled 91 consecutive patients with hepatitis B virus (HBV)-related chronic liver disease (CLD) who underwent both LB and LSM between September 2007 and January 2009. RESULTS: The mean age of the patients was 45.4 years (66 men and 25 women). F1 fibrosis was noted in 12 patients (13.2%), F2 in 28 (30.7%), F3 in 15 (16.5%) and F4 in 36 (39.6%). The mean LSM values from the fifth, sixth and seventh ICS were 11.6, 11.1 and 10.9 kPa respectively. The mean LSM value from the same site as LB was 11.0 kPa. An interclass correlation analysis showed no significant difference in LSM values from the fifth, sixth and seventh ICS and the same site as LB. The area under the receiver operating characteristic curves of LSM values from the fifth, sixth and seventh ICS and the same site as LB for predicting significant fibrosis were 0.815, 0.838, 0.818 and 0.837, respectively, and those for cirrhosis were 0.919, 0.916, 0.907 and 0.913, respectively, with all overlapping confidence intervals. CONCLUSIONS: Any LSM value from the fifth, sixth or seventh ICS can predict significant fibrosis and cirrhosis with considerable accuracy without statistical differences regardless of correspondence with LB site in patients with HBV-related CLD.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Jung Min(이중민)
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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