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Cited 43 times in

Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

DC Field Value Language
dc.contributor.author김원호-
dc.contributor.author김은수-
dc.contributor.author김태일-
dc.contributor.author천재희-
dc.contributor.author김승원-
dc.date.accessioned2015-04-24T16:38:31Z-
dc.date.available2015-04-24T16:38:31Z-
dc.date.issued2009-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103897-
dc.description.abstractThe plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCANCER LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntineoplastic Agents, Phytogenic/pharmacology*-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHBH3 Interacting Domain Death Agonist Protein/metabolism-
dc.subject.MESHBaculoviral IAP Repeat-Containing 3 Protein-
dc.subject.MESHCaspase 3/metabolism-
dc.subject.MESHCaspase 9/metabolism-
dc.subject.MESHCell Proliferation/drug effects*-
dc.subject.MESHColorectal Neoplasms/drug therapy*-
dc.subject.MESHColorectal Neoplasms/metabolism-
dc.subject.MESHColorectal Neoplasms/pathology-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEnzyme Activation-
dc.subject.MESHHT29 Cells-
dc.subject.MESHHumans-
dc.subject.MESHInhibitor of Apoptosis Proteins/metabolism-
dc.subject.MESHJNK Mitogen-Activated Protein Kinases/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHPhosphorylation-
dc.subject.MESHPregnenediones/pharmacology*-
dc.subject.MESHProto-Oncogene Proteins c-bcl-2/metabolism-
dc.subject.MESHProto-Oncogene Proteins c-jun/metabolism-
dc.subject.MESHTime Factors-
dc.subject.MESHUbiquitin-Protein Ligases-
dc.subject.MESHXenograft Model Antitumor Assays-
dc.subject.MESHfas Receptor/metabolism-
dc.titleGuggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMin Ji An-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorEun Soo Kim-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi10.1016/j.canlet.2009.01.026-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA04030-
dc.contributor.localIdA00804-
dc.relation.journalcodeJ00448-
dc.identifier.eissn1872-7980-
dc.identifier.pmid19232820-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304383509000603-
dc.subject.keywordGuggulsterone-
dc.subject.keywordColorectal cancer-
dc.subject.keywordApoptosis-
dc.subject.keywordXenograft-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.citation.volume279-
dc.citation.number1-
dc.citation.startPage93-
dc.citation.endPage100-
dc.identifier.bibliographicCitationCANCER LETTERS, Vol.279(1) : 93-100, 2009-
dc.identifier.rimsid37865-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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