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Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원호 | - |
dc.contributor.author | 김은수 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 김승원 | - |
dc.date.accessioned | 2015-04-24T16:38:31Z | - |
dc.date.available | 2015-04-24T16:38:31Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103897 | - |
dc.description.abstract | The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/pharmacology* | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | BH3 Interacting Domain Death Agonist Protein/metabolism | - |
dc.subject.MESH | Baculoviral IAP Repeat-Containing 3 Protein | - |
dc.subject.MESH | Caspase 3/metabolism | - |
dc.subject.MESH | Caspase 9/metabolism | - |
dc.subject.MESH | Cell Proliferation/drug effects* | - |
dc.subject.MESH | Colorectal Neoplasms/drug therapy* | - |
dc.subject.MESH | Colorectal Neoplasms/metabolism | - |
dc.subject.MESH | Colorectal Neoplasms/pathology | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | HT29 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inhibitor of Apoptosis Proteins/metabolism | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Pregnenediones/pharmacology* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-jun/metabolism | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Ubiquitin-Protein Ligases | - |
dc.subject.MESH | Xenograft Model Antitumor Assays | - |
dc.subject.MESH | fas Receptor/metabolism | - |
dc.title | Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Min Ji An | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Seung Won Kim | - |
dc.contributor.googleauthor | Eun Soo Kim | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 10.1016/j.canlet.2009.01.026 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A04030 | - |
dc.contributor.localId | A00804 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 19232820 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383509000603 | - |
dc.subject.keyword | Guggulsterone | - |
dc.subject.keyword | Colorectal cancer | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Xenograft | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Eun Soo | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Eun Soo | - |
dc.citation.volume | 279 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 93 | - |
dc.citation.endPage | 100 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.279(1) : 93-100, 2009 | - |
dc.identifier.rimsid | 37865 | - |
dc.type.rims | ART | - |
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