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Factors contributing to the development of restless legs syndrome in patients with Parkinson disease

Authors
 Ji E. Lee  ;  Hae-Won Shin  ;  Kyung S. Kim  ;  Young H. Sohn 
Citation
 MOVEMENT DISORDERS, Vol.24(4) : 579-582, 2009 
Journal Title
MOVEMENT DISORDERS
ISSN
 0885-3185 
Issue Date
2009
MeSH
Aged ; Disability Evaluation ; Female ; Humans ; Korea/epidemiology ; Logistic Models ; Male ; Middle Aged ; Parkinson Disease/epidemiology* ; Prevalence ; Restless Legs Syndrome/diagnosis* ; Restless Legs Syndrome/epidemiology* ; Severity of Illness Index ; Surveys and Questionnaires
Keywords
Parkinson disease ; restless legs syndrome ; dopamine
Abstract
Although restless legs syndrome (RLS) commonly accompanies Parkinson disease (PD), the mechanism of RLS development in PD is still unclear. We investigated the prevalence of RLS in Korean patients with PD, and the possible contributing factors to the development of RLS in those patients. Four hundred forty-seven consecutive patients with PD were interviewed and examined. Among them, 73 patients (16.3%) were diagnosed with RLS. PD patients with RLS had a longer duration of PD symptoms, more severe PD disability, a greater degree of cognitive decline, and a longer duration of antiparkinson therapy than those without RLS. Multivariate logistic regression analysis revealed that the duration of antiparkinson therapy was the most significant factor contributing to the development of RLS in patients with PD. The present results support a higher prevalence of RLS in patients with PD and suggest that long-term antiparkinson therapy, rather than PD itself, may contribute to the development of RLS.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mds.22410/abstract
DOI
10.1002/mds.22410
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103861
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