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The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: cardiovascular risks and adiponectin in IFG

Authors
 J.S. Nam  ;  J.S. Park  ;  M.H. Cho  ;  S.H. Jee  ;  H.S. Lee  ;  C.W. Ahn  ;  W.L. Lowe  ;  K.R. Kim 
Citation
 DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.84(2) : 145-151, 2009 
Journal Title
 DIABETES RESEARCH AND CLINICAL PRACTICE 
ISSN
 0168-8227 
Issue Date
2009
MeSH
Adiponectin/blood* ; Adult ; Blood Glucose/analysis ; Blood Pressure ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology* ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cross-Sectional Studies ; Glucose Intolerance/blood* ; Glucose Intolerance/physiopathology* ; Humans ; Insulin/blood ; Metabolic Syndrome/blood* ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/physiopathology* ; Middle Aged ; Peripheral Vascular Diseases/blood ; Peripheral Vascular Diseases/epidemiology ; Peripheral Vascular Diseases/physiopathology ; Pulse* ; Risk Factors
Keywords
Impaired fasting glucose ; Metabolic syndrome ; Adiponectin ; Pulse wave
Abstract
We aimed to assess how metabolic profiles, surrogate markers of insulin resistance, and subclinical atherosclerosis are interrelated in subjects with impaired fasting glucose (IFG) and investigate whether the diagnosis of metabolic syndrome (MetS) further increases the risk of cardiovascular disease among subjects already at risk. We analyzed 1739 Korean subjects with IFG. The parameters of MetS, plasma adiponectin level, and pulse wave velocity (PWV) were assessed. Subjects with MetS had unfavorable metabolic parameters, lower adiponectin level, and higher peripheral PWV compared to those without MetS. Adiponectin correlated with fasting glucose, waist circumference, triglyceride, HDL-cholesterol, BMI, HOMA-IR, and the number of MetS components. In addition to blood pressure, peripheral PWV was associated with triglyceride, waist circumference, and the number of MetS components while aortic PWV correlated positively with fasting plasma glucose. Multiple linear regression analysis revealed that adiponectin correlated with HDL-cholesterol, HOMA-IR, fasting glucose, waist circumference, and triglyceride, peripheral PWV with blood pressure, body mass index, waist circumference, and the number of MetS components, and aortic PWV with fasting plasma glucose. In subjects with IFG, concurrent MetS increases PWV and has an unfavorable effect on cardiovascular risks, and these risks were further increased by additional MetS components.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168822709000680
DOI
10.1016/j.diabres.2009.02.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Cho, Min Ho(조민호)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103732
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