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Serum adiponectin as a useful marker for metabolic syndrome in type 2 diabetic patients

Authors
 Ji Eun Yun  ;  Jae Woong Sull  ;  Hee Yeon Lee  ;  Eunjung Park  ;  Soriwool Kim  ;  Jaeseong Jo  ;  Sun Ju Lee  ;  Sang Yeon Kim  ;  Young Ju Choi  ;  Sun Ha Jee  ;  Kap Bum Huh 
Citation
 DIABETES-METABOLISM RESEARCH AND REVIEWS, Vol.25(3) : 259-265, 2009 
Journal Title
DIABETES-METABOLISM RESEARCH AND REVIEWS
ISSN
 1520-7552 
Issue Date
2009
MeSH
Adiponectin/blood* ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood* ; Diabetes Mellitus, Type 2/complications ; Female ; Humans ; Insulin Resistance ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/etiology ; Middle Aged ; Risk Factors
Abstract
BACKGROUND: Although adiponectin is generally known as a predictor of metabolic syndrome, potential of adiponectin as a predictor for metabolic syndrome in type 2 diabetes is debated. The purpose of this study is to determine the association between adiponectin and metabolic syndrome in patients with type 2 diabetes. METHODS: Adiponectin and the risk of metabolic syndrome were examined among 1013 type 2 diabetes patients who visited Huh's Diabetes Center from January 2003 to June 2006. Adiponectin levels were classified into quartile groups, and metabolic syndrome was defined according to the standard of National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III. Insulin sensitivity was directly assessed using the short insulin tolerance test (SITT) (Kitt: %/ min). RESULTS: Adiponectin was significantly correlated with metabolic syndrome components. The age-adjusted correlations between adiponectin and clinical parameters including metabolic components were significant; adiponectin was negatively correlated with waist circumference, diastolic blood pressure and triglyceride, and positively correlated with high-density lipoprotein (HDL) cholesterol. Subjects with metabolic syndrome showed lower adiponectin levels than those without metabolic syndrome. After multivariate adjustment, participants with lower adiponectin levels also had a higher risk for metabolic syndrome (OR for lowest quartiles 2.21; 95% CI, 1.51-3.24). Metabolic syndrome risk was stronger among those with low adiponectin and severe insulin resistance simultaneously. This study has shown additive effects of adiponectin and insulin resistance on metabolic syndrome. CONCLUSIONS: In type 2 diabetic patients, the adiponectin was a useful predictor of metabolic syndrome independent of potential confounding variables.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/dmrr.946/abstract
DOI
10.1002/dmrr.946
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Sull, Jae Woong(설재웅)
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103712
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