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Postoperative adjuvant chemotherapy of gastric cancer: scrutiny into the clinical evidence based on quality assessment of medical literature of randomized controlled trials

DC FieldValueLanguage
dc.contributor.author안중배-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.contributor.author노성훈-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author박찬희-
dc.contributor.author신상준-
dc.date.accessioned2015-04-24T16:29:31Z-
dc.date.available2015-04-24T16:29:31Z-
dc.date.issued2009-
dc.identifier.issn0344-5704-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103613-
dc.description.abstractThe aim of this study was to scrutinize the evidence of adjuvant chemotherapy of gastric cancer by assessing the quality of the medical literature of randomized controlled trials (RCTs). A quality assessment (QA) scoring system was devised with the three parameters-control of bias, quality of report, and quality of design-which consisted 19 items. We searched for all the publications of the RCTs, from 1969 to 2007, with surgery-only arm, and their associated meta-analyses to score. Among the 26 RCTs, quality of three articles were graded as (2+), 10 articles as (1+), and 13 articles as (-). Recently published studies had overall better quality of report, but not necessarily better quality of design. Three studies demonstrating a positive survival benefit of adjuvant chemotherapy had a grade (1+). Hierarchical clustering revealed that the 26 articles were grouped into three major branches associated with study quality and a multi-institutional setting. We also obtained a statistically significant set of ten items (P < 0.001) that could differentiate articles of good (1-2+) and low quality (-) through supervised two-way hierarchical clustering. Finally, the level of recommendation for adjuvant chemotherapy in gastric cancer was to be a "B" according to the Scottish Intercollegiate Guidelines Network (SIGN) System. QA of medical literature should be an essential consideration for medical-related decision-making and the formation of evidence-based guidelines. Multidisciplinary discussion to develop and refine trial design is important for procuring better quality of RCTs of adjuvant chemotherapy of gastric cancer-
dc.description.statementOfResponsibilityopen-
dc.format.extent919~927-
dc.relation.isPartOfCANCER CHEMOTHERAPY AND PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/drug therapy*-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHEvidence-Based Medicine-
dc.subject.MESHHumans-
dc.subject.MESHPostoperative Period-
dc.subject.MESHQuality Assurance, Health Care-
dc.subject.MESHRandomized Controlled Trials as Topic-
dc.subject.MESHStomach Neoplasms/drug therapy*-
dc.titlePostoperative adjuvant chemotherapy of gastric cancer: scrutiny into the clinical evidence based on quality assessment of medical literature of randomized controlled trials-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorChan Hee Park-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyun Cheol Chung-
dc.identifier.doi10.1007/s00280-008-0808-5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02262-
dc.contributor.localIdA03773-
dc.contributor.localIdA01281-
dc.contributor.localIdA01290-
dc.contributor.localIdA01712-
dc.contributor.localIdA02105-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ00437-
dc.identifier.eissn1432-0843-
dc.identifier.pmid18712389-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00280-008-0808-5-
dc.subject.keywordAdjuvant chemotherapy-
dc.subject.keywordGastric adenocarcinoma-
dc.subject.keywordInformation retrieval-
dc.subject.keywordRandomized controlled trial-
dc.subject.keywordQuality assessment-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Chan Hee-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorPark, Chan Hee-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.citation.volume63-
dc.citation.number5-
dc.citation.startPage919-
dc.citation.endPage927-
dc.identifier.bibliographicCitationCANCER CHEMOTHERAPY AND PHARMACOLOGY, Vol.63(5) : 919-927, 2009-
dc.identifier.rimsid37953-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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