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Abnormal brain response during the auditory emotional processing in schizophrenic patients with chronic auditory hallucinations

Authors
 Jee In Kang  ;  Jae-Jin Kim  ;  Jeong-Ho Seok  ;  JiWon Chun  ;  Seung-Koo Lee  ;  Hae-Jeong Park 
Citation
 Schizophrenia Research, Vol.107(1) : 83-91, 2009 
Journal Title
 Schizophrenia Research 
ISSN
 0920-9964 
Issue Date
2009
Abstract
OBJECTIVE: Few neuroimaging studies have been conducted regarding clinical associations between auditory hallucinations (AHs) and affective disturbances in patients with schizophrenia. This study aimed to elucidate the neurobiological basis of emotional disturbances in schizophrenic patients with persisting AHs. METHODS: Using functional magnetic resonance imaging (fMRI), the cortical responsiveness during the processing of laughing and crying sounds was measured and compared between 14 hallucinating schizophrenic patients, 14 nonhallucinating schizophrenic patients and 28 normal controls. RESULTS: The hallucinating patients showed differential neural activities in various areas including the amygdala, the hippocampus, the cingulate, the prefrontal cortex, and the parietal cortex, compared with the nonhallucinating patients and the normal controls. In particular, compared with the nonhallucinators, the hallucinators revealed reduced activation in the left amygdala and the bilateral hippocampus during the processing of crying sounds. CONCLUSION: Our findings suggest that the persistence of AHs in schizophrenia may induce functional disturbances of the emotion-related interconnected neural networks, including reduced responsiveness in the amygdala and hippocampus to negative stimuli
Full Text
http://www.sciencedirect.com/science/article/pii/S0920996408003770
DOI
10.1016/j.schres.2008.08.019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103522
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