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인공혈액의 현재와 전망 : 적혈구 대용제제를 중심으로

Other Titles
 Current Status and Future of Artificial Blood- Focusing on Red Blood Cell Substitutes 
Authors
 김종훈  ;  이기영 
Citation
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION , Vol.52(2) : 168-181, 2009 
Journal Title
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION 
ISSN
 1975-8456 
Issue Date
2009
Keywords
Blood substitute ; Red blood cell substitute ; Hemoglobin based oxygen carrier
Abstract
Blood substitutes, especially red blood cell (RBC) substitutes, have been developed for the past five decades and have several advantages over allogenic packed RBCs, including a prolonged half-life, lack of a cross-matching requirement, and minimal infection risk or concerns about immunologic reactions. There are two main groups in RBC substitutes: perfluorochemicals and hemoglobin-based oxygen carriers (HBOCs). HBOCs are made of hemoglobins from:human, bovine or recombinant and undergo three modification types: chemical (intramolecular cross-linking, polymerization, conjugation to macromolecules and combination of several chemical modifications), genetic, or technological (microencapsulation). The types, side effects, current status of clinical trials, and the future of HBOCs are described in details
Files in This Item:
T200900555.pdf Download
DOI
10.5124/jkma.2009.52.2.168
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Hoon(김종훈)
Lee, Ki Young(이기영) ORCID logo https://orcid.org/0000-0003-4893-3195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103497
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