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G allele at RAGE SNP82 is associated with proinflammatory markers in obese subjects

Authors
 Yoen Kim  ;  Seog Hyun Jo  ;  Yangsoo Jang  ;  Jey Sook Chae  ;  Ji Young Kim  ;  Yae Jung Hyun  ;  Jong Ho Lee 
Citation
 NUTRITION RESEARCH, Vol.29(2) : 106-113, 2009 
Journal Title
 NUTRITION RESEARCH 
ISSN
 0271-5317 
Issue Date
2009
MeSH
Alcohol Drinking ; Asian Continental Ancestry Group ; Biomarkers/blood ; Body Mass Index ; C-Reactive Protein/metabolism ; Cytokines/blood ; Gene Frequency ; Glycation End Products, Advanced/blood ; Glycation End Products, Advanced/genetics* ; Homozygote ; Humans ; Inflammation/genetics* ; Male ; Middle Aged ; Obesity/genetics* ; Polymorphism, Genetic* ; Protein Isoforms ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic/genetics* ; Smoking
Keywords
RAGEG82S ; sRAGE ; AGEs ; hs-CRP ; Humans ; Obesity
Abstract
Obesity is closely associated with low-grade inflammation. The Gly82Ser (G82S) polymorphism in the receptor for the advanced glycation end products (RAGE) gene related to RAGE expression is also involved in inflammatory response. We examined the association between RAGEG82S and obesity on soluble RAGE (sRAGE) and inflammatory markers in Korean men. The following were measured: anthropometric and biochemical parameters, RAGEG82S polymorphism, sRAGE, advanced glycation end products (AGEs), and inflammatory markers in men (n = 1252; range, 30-70 years; body mass index [BMI], > or =18.5 kg/m(2)). Allele frequencies satisfied Hardy-Weinberg Equilibrium (G/G: 72.2%, G/S: 25.5%, S/S: 2.3%). RAGEG82S (beta-coefficient = -0.384, P < .001) and BMI (beta-coefficient = -0.168, P = .001) were major factors affecting sRAGE concentrations. In all subjects, those with 'S/S' homozygotes showed the lowest levels of sRAGE (G/G: 1036.3 +/- 40.3, G/S: 807.0 +/- 49.6, S/S: 443.0 +/- 47.8 pg/mL) before (P < .001) and after adjusted for age, BMI, cigarette smoking, and alcohol drinking (P < .001). When subdivided according to BMI of 25 kg/m(2) (Asian Pacific guideline), obese subjects (BMI > or =25 kg/m(2)) had significantly lower levels of sRAGE (831.7 +/- 36.7 vs 1022.7 +/- 47.8 pg/mL, P = .009) and higher levels of high sensitivity C-reactive protein (hs-CRP) (1.10 +/- 0.07 vs 0.72 +/- 0.05 mg/dL, P < .001) compared with nonobese subjects (BMI <25 kg/m(2)). Particularly in obese subjects, S/S carriers showed significantly higher concentrations of AGEs (P = .012) and hs-CRP (P = .006) than G allele carriers, whereas nonobese people had no significant RAGEG82S-related differences in AGEs (P = .743) and hs-CRP (P = .436). In conclusion, G allele at RAGEG82S may be more associated with inflammatory markers under obese status than nonobese conditions. In this case, it may help to suggest proper dietary modification for controlling obesity to people with genetic variants.
Full Text
http://www.sciencedirect.com/science/article/pii/S0271531709000207
DOI
10.1016/j.nutres.2009.01.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103481
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