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The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease

Authors
 Yangsoo Jang  ;  Jean Kyung Paik  ;  Yae Jung Hyun  ;  Jey Sook Chae  ;  Ji Young Kim  ;  Ju Ree Choi  ;  Sang Hak Lee  ;  Dong-Jik Shin  ;  Jose M. Ordovas  ;  Jong Ho Lee 
Citation
 CLINICA CHIMICA ACTA, Vol.402(1-2) : 83-87, 2009 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2009
MeSH
Alleles ; Apolipoprotein A-V ; Apolipoproteins A/blood ; Apolipoproteins A/genetics* ; Cholesterol, LDL/blood ; Cholesterol, LDL/metabolism ; Coronary Artery Disease/blood ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics* ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Triglycerides/blood
Keywords
APOA5 -1131T>C polymorphism ; Coronary artery disease ; Triglycerides ; Apolipoprotein A5 concentration ; LDL particle size
Abstract
BACKGROUND: The association between -1131T>C single nucleotide polymorphism (SNP) of the apolipoprotein A5 gene (APOA5) and hypertriglyceridemia raised the possibility that this SNP could be related to coronary artery disease (CAD) risk. Therefore, we investigated the association of this APOA5 -1131T>C SNP with circulating concentrations of APOA5, triglyceride and CAD in Koreans. METHODS: CAD patients (n=741) and age-, sex-matched healthy controls (n=741) were genotyped for the APOA5 -1131T>C SNP. The main outcome measures were the odds ratio (OR) on CAD risk and lipid variables, APOA5 concentration and LDL particle size. RESULTS: The presence of the minor allele at the -1131T>C SNP was associated with an increased risk of CAD [OR 1.34 (95% CI, 1.09-1.65), P=0.007] after adjusting for BMI, alcohol consumption, systolic blood pressure and diastolic blood pressure. There was an association between the APOA5 concentration and the -1131T>C genotype in controls (T/T: 245+/-7 ng/ml, T/C: 220+/-6, C/C: 195+/-12; P=0.001) and CAD patients (T/T: 218+/-8 ng/ml, T/C: 185+/-7, C/C: 169+/-12; P<0.001). Subjects with T/C or C/C in control and CAD patient groups showed higher triglyceride than those with T/T genotype. Also, the -1131T>C polymorphism was associated with LDL particle size (P=0.003), with the T/C or C/C controls having smaller size than the T/T controls. CONCLUSIONS: The APOA5 -1131C allele is associated with reduced APOA5 concentration and with increased CAD risk. This is consistent with the observed association between the -1131C SNP, increased triglycerides as well as small LDL particle size.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898108006293
DOI
10.1016/j.cca.2008.12.024
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103480
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