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Differential diagnosis of intestinal Behçet's disease and Crohn's disease by colonoscopic findings

Authors
 S. K. Lee  ;  B. K. Kim  ;  T. I. Kim  ;  W. H. Kim 
Citation
 ENDOSCOPY, Vol.41(1) : 9-16, 2009 
Journal Title
 ENDOSCOPY 
ISSN
 0013-726X 
Issue Date
2009
MeSH
Adolescent ; Adult ; Behcet Syndrome/diagnosis* ; Colonoscopy ; Crohn Disease/diagnosis* ; Diagnosis, Differential ; Female ; Humans ; Intestinal Diseases/diagnosis* ; Male ; Middle Aged ; Young Adult
Abstract
BACKGROUND AND STUDY AIMS: Intestinal Behçet's disease and Crohn's disease are chronic inflammatory bowel diseases that are difficult to distinguish from each other. We investigated their colonoscopic features and identified simple and valuable strategies for differential diagnosis. PATIENTS AND METHODS: Between 1995 and 2006, 250 consecutive patients with ulcers on colonoscopy (115 Behçet's, 135 Crohn's cases) were reviewed. All patients with Behçet's fulfilled the criteria of the International Study Group for Behçet's Disease or of the Behçet's Disease Research Committee of Japan, while Crohn's disease was confirmed by clinicopathological data. Patients were randomly allocated to a training set (70 %) or a validation set (30 %). Ulcer shapes, distributions, numbers, margins, and border contours, and the presence of aphthous, cobblestone, perianal, and strictured lesions were compared, in the training set. Univariate and multivariate analysis were performed, using the X2-test and logistic regression. In addition, a classification and regression tree (CART) was then used to generate simplified algorithms for differential diagnosis. RESULTS: Round shape, five or fewer in number, focal distributions, and absence of aphthous and cobblestone lesions were significantly dominant features in Behçet's disease, according to multivariate analysis of the training set. The CART-generated algorithms proposed sequential use of shape (round, irregular/geographic, or longitudinal) and distribution (focal single/focal multiple, or segmental/diffuse). Diagnosis of Behçet's disease in the validation set produced sensitivity, specificity, and negative and positive predictive values of 94.3 %, 90.0 %, 94.7 %, and 89.2 %, respectively. Using the CART model, we made the correct diagnosis of intestinal Behçet's disease or Crohn's disease in 69 of 75 patients (92 %). CONCLUSION: It was determined that round and longitudinal ulcers are suggestive of Behçet's disease and Crohn's disease, respectively. Irregular/geographic-shaped ulcers and focal distributions are suggestive of Behçet's disease, while segmental/diffuse lesions suggest Crohn's
Full Text
https://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1103481
DOI
10.1055/s-0028-1103481
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103468
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