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Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action.

Authors
 YOU-JOUNG KIM  ;  HYUN-JUNG PARK  ;  GWANG LEE  ;  OH YOUNG BANG  ;  YOUNG HWAN AHN  ;  EUNHYE JOE  ;  HYUN OK KIM  ;  PHIL HYU LEE 
Citation
 GLIA, Vol.57(1) : 13-23, 2009 
Journal Title
 GLIA 
ISSN
 0894-1491 
Issue Date
2009
MeSH
Animals ; Cells, Cultured ; Coculture Techniques ; Dopamine/physiology* ; Humans ; Inflammation/pathology ; Inflammation/prevention & control* ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/physiology ; Male ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stromal Cells*/cytology ; Mice ; Mice, Inbred C57BL ; Microglia/pathology ; Microglia/physiology ; Neurons/pathology* ; Neurons/physiology ; Parkinson Disease/pathology ; Parkinson Disease/prevention & control ; Rats ; Rats, Sprague-Dawley
Keywords
mesenchymal stem cells ; neuroprotective effect ; anti-inflam-matory ; Parkinson’s disease
Abstract
Parkinson's disease (PD) is a common, progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (SN). Numerous studies have provided evidence suggesting that neuroinflammation plays an important role in the pathogenesis of PD. In this study, we used lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models to investigate whether human mesenchymal stem cells (hMSCs) have a protective effect on the dopaminergic system through anti-inflammatory mechanisms. The hMSC treatment significantly decreased LPS-induced microglial activation, tumor necrosis factor (TNF)-alpha, inducible nitric oxide synthase (iNOS) mRNA expression, and production of NO and TNF-alpha compared with the LPS-only treatment group. In co-cultures of microglia and mesencephalic dopaminergic neurons, hMSC treatment significantly decreased the loss of tyrosine hydroxylase-immunopositive (TH-ip) cells. The hMSC treatment in rats showed that TH-ip neuronal loss induced by LPS stimulation in the SN was considerably decreased and was clearly accompanied by a decrease in activation of microglia, as well as TNF-alpha and iNOS mRNA expression and production of TNF-alpha. These data suggest that hMSCs have a neuroprotective effect on dopaminergic neurons through anti-inflammatory actions mediated by the modulation of microglial activation. Along with various trophic effects and trans-differentiational potency, the anti-inflammatory properties of MSCs could have major therapeutic implications in the treatment of PD
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/glia.20731/abstract
DOI
10.1002/glia.20731
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103466
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