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Short-term safety and efficacy of a single intravitreal bevacizumab injection for the management of polypoidal choroidal vasculopathy

DC Field Value Language
dc.contributor.author고형준-
dc.contributor.author권오웅-
dc.contributor.author변석호-
dc.contributor.author송지훈-
dc.contributor.author이성철-
dc.date.accessioned2015-04-24T16:24:34Z-
dc.date.available2015-04-24T16:24:34Z-
dc.date.issued2009-
dc.identifier.issn0030-3755-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103460-
dc.description.abstractAIMS: To evaluate the short-term safety and efficacy of a single intravitreal bevacizumab injection in patients with polypoidal choroidal vasculopathy (PCV). METHODS: The records of patients treated with intravitreal bevacizumab for PCV were retrospectively reviewed. All patients were evaluated by complete ophthalmic examination, optical coherence tomography and fluorescein and indocyanine green angiography. Changes in visual acuity and central retinal thickness (CRT) over 3 months were the main outcome measures. RESULTS: Nineteen eyes of 18 patients were included. No serious ocular or systemic adverse events were observed. The median baseline visual acuity and CRT were 20/100 and 230 microm, respectively. After 1 month, there was no significant improvement in median visual acuity (20/80(+1); p = 0.055), but median CRT had decreased significantly (160 microm; p < 0.001). After 3 months (data available for 17 eyes), both median visual acuity (20/63(-2); p = 0.001) and CRT (190 microm; p = 0.007) showed significant improvements over baseline values. CONCLUSIONS: Intravitreal bevacizumab therapy for PCV was well tolerated over the 3-month follow-up period. Short-term results are promising, but further studies are necessary to evaluate long-term efficacy-
dc.description.statementOfResponsibilityopen-
dc.format.extent85~92-
dc.relation.isPartOfOPHTHALMOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAngiogenesis Inhibitors/administration & dosage*-
dc.subject.MESHAntibodies, Monoclonal/administration & dosage*-
dc.subject.MESHAntibodies, Monoclonal, Humanized-
dc.subject.MESHBevacizumab-
dc.subject.MESHChoroidal Neovascularization/drug therapy*-
dc.subject.MESHChoroidal Neovascularization/pathology-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, Optical Coherence-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVisual Acuity/drug effects-
dc.subject.MESHVitreous Body-
dc.titleShort-term safety and efficacy of a single intravitreal bevacizumab injection for the management of polypoidal choroidal vasculopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorJi Hun Song-
dc.contributor.googleauthorSuk Ho Byeon-
dc.contributor.googleauthorSung Chul Lee-
dc.contributor.googleauthorHyoung Jun Koh-
dc.contributor.googleauthorOh Woong Kwon-
dc.identifier.doi10.1159/000175312-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00152-
dc.contributor.localIdA00235-
dc.contributor.localIdA01849-
dc.contributor.localIdA02065-
dc.contributor.localIdA02873-
dc.relation.journalcodeJ02431-
dc.identifier.eissn1423-0267-
dc.identifier.pmid19023226-
dc.identifier.urlhttp://www.karger.com/Article/FullText/175312-
dc.subject.keywordPolypoidal choroidal vasculopathy-
dc.subject.keywordChoroidal neovascularization-
dc.subject.keywordVascular endothelial growth factor-
dc.subject.keywordBevacizumab-
dc.subject.keywordIntravitreal injection-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.alternativeNameKwon, Oh Woong-
dc.contributor.alternativeNameByeon, Suk Ho-
dc.contributor.alternativeNameSong, Ji Hun-
dc.contributor.alternativeNameLee, Sung Chul-
dc.contributor.affiliatedAuthorKoh, Hyoung Jun-
dc.contributor.affiliatedAuthorKwon, Oh Woong-
dc.contributor.affiliatedAuthorByeon, Suk Ho-
dc.contributor.affiliatedAuthorSong, Ji Hun-
dc.contributor.affiliatedAuthorLee, Sung Chul-
dc.citation.volume223-
dc.citation.number2-
dc.citation.startPage85-
dc.citation.endPage92-
dc.identifier.bibliographicCitationOPHTHALMOLOGICA, Vol.223(2) : 85-92, 2009-
dc.identifier.rimsid36018-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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