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Classic risk factors for atherosclerosis are not major determinants for location of extracranial or intracranial cerebral atherosclerosis

Authors
 Young Dae Kim  ;  Hye Yeon Choi  ;  Yo Han Jung  ;  Chung Mo Nam  ;  Jae Hoon Yang  ;  Han Jin Cho  ;  Hyo Suk Nam  ;  Kyung-Yul Lee  ;  Ji Hoe Heo 
Citation
 NEUROEPIDEMIOLOGY, Vol.32(3) : 201-207, 2009 
Journal Title
 NEUROEPIDEMIOLOGY 
ISSN
 0251-5350 
Issue Date
2009
MeSH
Adult ; Aged ; Aged, 80 and over ; Atherosclerosis/classification ; Atherosclerosis/epidemiology ; Atherosclerosis/etiology ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Intracranial Arteriosclerosis/classification* ; Intracranial Arteriosclerosis/epidemiology* ; Intracranial Arteriosclerosis/etiology ; Male ; Middle Aged ; Registries ; Risk Factors ; Smoking/adverse effects ; Smoking/epidemiology ; Young Adult
Keywords
Cerebral arteries ; Atherosclerosis ; Stroke ; Cerebral angiography
Abstract
BACKGROUND: The prevalence of extracranial (EC) and intracranial (IC) atherosclerosis varies among races. Although several studies have sought to identify specific vascular risk factors that are associated with EC or IC atherosclerosis, the exact relationships are uncertain. This study aimed to determine if there are any specific risk factors for EC or IC atherosclerosis. METHODS: For this study, we considered 3,349 consecutive patients who had been entered into a stroke registry between January 1999 and June 2007. After the exclusion of patients who had not undergone angiography, patients with cardiac sources of embolism or other causes of stroke, and non-Koreans, we had a total of 2,169 patients of single ethnicity with an angiographic analysis. Patients with atherosclerosis in both the IC and EC arteries (856 patients) were excluded. Finally, we identified 1,313 patients who had EC atherosclerosis (EC group, n = 256), IC atherosclerosis (IC group, n = 566) or normal angiographic findings (no-lesion group, n = 488). The frequency of risk factors and the demographic parameters were compared among these groups. RESULTS: When compared to the normal group, the IC group was associated with older age and hypertension, and the EC group was associated with older age, higher initial blood sugar and low-density lipoprotein cholesterol levels. However, in a direct comparison between the IC and EC groups, we did not observe any significant risk factors or variables except for a higher frequency of males and higher total cholesterol levels in the EC group. CONCLUSIONS: Vascular risk factors may not be major determinants of location for atherosclerosis in the EC or IC arteries.
Full Text
http://www.karger.com/Article/FullText/195690
DOI
10.1159/000195690
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Yang, Jae Hoon(양재훈)
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Jung, Yo Han(정요한)
Cho, Han Jin(조한진)
Choi, Hye Yoen(최혜연)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103405
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