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Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents

 Jung-Sun Kim  ;  Seung-Yul Lee  ;  Jung Myung Lee  ;  Young Won Yoon  ;  Chul-Min Ahn  ;  Myung-Hyun Kim  ;  Pil-Ki Min  ;  Young-Guk Ko  ;  Bum-Kee Hong  ;  Donghoon Choi  ;  Hyuck Moon Kwon  ;  Yangsoo Jang  ;  Won-Heum Shim 
 Coronary Artery Disease, Vol.20(1) : 59-63, 2009 
Journal Title
 Coronary Artery Disease 
Issue Date
BACKGROUND: Several reports have suggested that stent fractures in sirolimus-eluting stents (SESs) might be related to in-stent restenosis (ISR). However, the role of stent strut fracture in ISR has not been clearly elucidated. Therefore, we investigated the association of the SES fracture and ISR. METHODS: From 2003 to 2006, SES implantations with follow-up coronary angiography (CAG) for 628 lesions in 557 patients were analyzed. We reviewed clinical and procedural factors that might affect SES fracture and ISR. the median time interval from stent implantation to follow-up CAG was 9 months (range: 2-30 months). RESULTS: ISR occurred in 38 patients (5.7%), and 21 stent fractures (3.3%) were identified by follow-up CAG. Fourteen cases occurred in the left anterior descending artery, and seven occurred in the right coronary artery. the binary ISR rate in the stent fracture group was higher compared with that of the nonfracture group (38.1% vs. 4.6%, P<0.001). Predictors of ISR as estimated by multivariate analysis were a stent diameter less than 2.75 mm [odds ratio (OR)=2.76, P=0.012], a stent length over 28 mm (OR=3.30, P=0.024), and stent fracture (OR=11.03, P<0.001) after controlling for the angiographic and clinical risk factors of ISR. CONCLUSION: Stent fracture was an independent predictor of ISR and may be one of the crucial mechanisms of ISR after implantation of an SES
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
고영국(Ko, Young Guk) ORCID logo https://orcid.org/0000-0001-7748-5788
권혁문(Kwon, Hyuck Moon) ORCID logo https://orcid.org/0000-0001-9901-5015
김중선(Kim, Jung Sun) ORCID logo https://orcid.org/0000-0003-2263-3274
민필기(Min, Pil Ki) ORCID logo https://orcid.org/0000-0001-7033-7651
심원흠(Shim, Won Heum)
안철민(Ahn, Chul-Min) ORCID logo https://orcid.org/0000-0002-7071-4370
윤영원(Yoon, Young Won) ORCID logo https://orcid.org/0000-0002-0907-0350
이승율(Lee, Seung Yul)
이정명(Lee, Jung Myung)
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
최동훈(Choi, Dong Hoon) ORCID logo https://orcid.org/0000-0002-2009-9760
홍범기(Hong, Bum Kee) ORCID logo https://orcid.org/0000-0002-6456-0184
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