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Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents

 Jung-Sun Kim  ;  Seung-Yul Lee  ;  Jung Myung Lee  ;  Young Won Yoon  ;  Chul-Min Ahn  ;  Myung-Hyun Kim  ;  Pil-Ki Min  ;  Young-Guk Ko  ;  Bum-Kee Hong  ;  Donghoon Choi  ;  Hyuck Moon Kwon  ;  Yangsoo Jang  ;  Won-Heum Shim 
 CORONARY ARTERY DISEASE, Vol.20(1) : 59-63, 2009 
Journal Title
Issue Date
Aged ; Angioplasty, Balloon, Coronary/instrumentation* ; Cardiovascular Agents/administration & dosage* ; Coronary Angiography ; Coronary Restenosis/diagnostic imaging ; Coronary Restenosis/etiology* ; Coronary Stenosis/therapy* ; Drug-Eluting Stents* ; Equipment Failure Analysis ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Prosthesis Failure* ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sirolimus/administration & dosage* ; Time Factors ; Treatment Outcome
restenosis ; sirolimus-eluting stent ; stent fracture
BACKGROUND: Several reports have suggested that stent fractures in sirolimus-eluting stents (SESs) might be related to in-stent restenosis (ISR). However, the role of stent strut fracture in ISR has not been clearly elucidated. Therefore, we investigated the association of the SES fracture and ISR. METHODS: From 2003 to 2006, SES implantations with follow-up coronary angiography (CAG) for 628 lesions in 557 patients were analyzed. We reviewed clinical and procedural factors that might affect SES fracture and ISR. the median time interval from stent implantation to follow-up CAG was 9 months (range: 2-30 months). RESULTS: ISR occurred in 38 patients (5.7%), and 21 stent fractures (3.3%) were identified by follow-up CAG. Fourteen cases occurred in the left anterior descending artery, and seven occurred in the right coronary artery. the binary ISR rate in the stent fracture group was higher compared with that of the nonfracture group (38.1% vs. 4.6%, P<0.001). Predictors of ISR as estimated by multivariate analysis were a stent diameter less than 2.75 mm [odds ratio (OR)=2.76, P=0.012], a stent length over 28 mm (OR=3.30, P=0.024), and stent fracture (OR=11.03, P<0.001) after controlling for the angiographic and clinical risk factors of ISR. CONCLUSION: Stent fracture was an independent predictor of ISR and may be one of the crucial mechanisms of ISR after implantation of an SES
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Min, Pil Ki(민필기) ORCID logo https://orcid.org/0000-0001-7033-7651
Shim, Won Heum(심원흠)
Ahn, Chul-Min(안철민) ORCID logo https://orcid.org/0000-0002-7071-4370
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Lee, Seung Yul(이승율)
Lee, Jung Myung(이정명)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
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