Cited 15 times in
In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 김용태 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 이정옥 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.date.accessioned | 2015-04-24T16:21:22Z | - |
dc.date.available | 2015-04-24T16:21:22Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0888-7543 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103375 | - |
dc.description.abstract | Gastric cancer is one of the most common cancers worldwide, and there are clinical caveats in predicting tumor response to chemotherapy. This study describes the construction of an in vitro pharmacogenomic database, and the selection of genes associated with chemosensitivity in gastric cancer cell lines. Gene expression and chemosensitivity databases were integrated using the Pearson correlation coefficient to give the GC-matrix. The 85 genes were selected that were commonly associated with chemosensitivity of the major anticancer drugs. We then focused on the genes that were highly correlated with each specific drug. Classification of cell lines based on the set of genes associated with each drug was consistent with the division into resistant or sensitive groups according to the chemosensitivity results. The GC-matrix of the gastric cancer cell line database was used to identify different sets of chemosensitivity-related genes for specific drugs or multiple drugs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 52~61 | - |
dc.relation.isPartOf | GENOMICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Databases, Genetic | - |
dc.subject.MESH | Drug Resistance, Neoplasm | - |
dc.subject.MESH | Gene Expression Profiling* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasm Proteins/genetics | - |
dc.subject.MESH | Neoplasm Proteins/metabolism* | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Stomach Neoplasms/drug therapy | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.title | In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Jae-Joon Jung | - |
dc.contributor.googleauthor | Hei-Cheul Jeung | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Jung Ok Lee | - |
dc.contributor.googleauthor | Tae Soo Kim | - |
dc.contributor.googleauthor | Yong Tai Kim | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.1016/j.ygeno.2008.08.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00753 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A03116 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00939 | - |
dc.identifier.eissn | 1089-8646 | - |
dc.identifier.pmid | 18804159 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0888754308001869 | - |
dc.subject.keyword | Pharmacogenomic database | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | Predictive marker | - |
dc.subject.keyword | Gastric cancer | - |
dc.contributor.alternativeName | Kim, Yong Tai | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Lee, Jung Ok | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Kim, Yong Tai | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Jung Ok | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 93 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 52 | - |
dc.citation.endPage | 61 | - |
dc.identifier.bibliographicCitation | GENOMICS, Vol.93(1) : 52-61, 2009 | - |
dc.identifier.rimsid | 37302 | - |
dc.type.rims | ART | - |
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