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Comparison of the validity of three biomarkers for gastric cancer screening: carcinoembryonic antigen, pepsinogens, and high sensitive C-reactive protein.

Authors
 Hye Won Chung  ;  Ju Won Kim  ;  Jong-han Lee  ;  Si Young Song  ;  Jae Bock Chung  ;  Oh Hun Kwon  ;  Jong-Baeck Lim 
Citation
 JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.43(1) : 19-26, 2009 
Journal Title
 JOURNAL OF CLINICAL GASTROENTEROLOGY 
ISSN
 0192-0790 
Issue Date
2009
MeSH
Adult ; Aged ; Biomarkers/blood ; C-Reactive Protein/metabolism* ; Carcinoembryonic Antigen/blood* ; Endoscopy, Gastrointestinal ; Female ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Neoplasm Metastasis ; Pepsinogens/blood* ; Predictive Value of Tests ; Prospective Studies ; Sensitivity and Specificity ; Stomach Neoplasms/blood ; Stomach Neoplasms/diagnosis* ; Stomach Neoplasms/pathology
Keywords
gastric cancer ; CEA ; pepsinogens ; hsCRP
Abstract
PURPOSE: To identify a desirable serum marker for screening tools for gastric cancer, we evaluated the validity of 3 biomarkers, namely, carcinoembryonic antigen (CEA), pepsinogens (PGs), and high sensitive C-reactive protein (hsCRP). METHODS: We estimated the mean serum levels of CEA, PGs, and hsCRP and compared the sensitivity and specificity of these 3 biomarkers in 378 subjects who were classified into 7 groups: normal, chronic atrophic gastritis, intestinal metaplasia, adenoma, early gastric cancer (EGC), advanced gastric cancer (AGC) without metastasis, and AGC with metastasis (M1). RESULTS: There were no significant differences among the normal, high-risk (chronic atrophic gastritis, intestinal metaplasia, and adenoma), and EGC groups for CEA and hsCRP. However, the levels of CEA were relatively higher in the AGC group with intestinal-type cancer (P<0.01). Likewise, hsCRP was relatively higher in the AGC group with diffuse-type cancer (P<0.01). For the PG I/II ratio, there was no significant difference among the normal, high-risk, and cancer groups, including EGC (P<0.01). In addition, there was a negative correlation with grades (gammas=-0.480, P<0.01). However, the PG I/II ratio was relatively less effective in diffuse-type cancer compared with intestinal-type cancer. The combination of serum hsCRP and the PG I/II ratio had a higher sensitivity (77%) than did the PG I/II ratio alone (61%) in diffuse-type cancers. CONCLUSIONS: The combination of serum hsCRP and PG I/II ratio would be helpful as a screening tool for gastric cancer in high incidence populations and may help to select high-risk subjects in need of further specific invasive screening tools such as endoscopy
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-200901000-00005&LSLINK=80&D=ovft
DOI
10.1097/MCG.0b013e318135427c
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Hun(권오헌)
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
Chung, Jae Bock(정재복)
Chung, Hye Won(정혜원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103345
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