유방암 환자에서 우울 및 불안 증상과 삶의 질과의 연관성

Abstract

Objectives：Patients with breast cancer may experience psychological distress after cancer diagnosis. Previous studies have reported that depressive symptoms in the patients with breast cancer may have a harmful effect on their prognosis and quality of life. The purpose of this study was to evaluate correlations between depressive and anxiety symptoms and their quality of life in breast cancer patients. Methods：Sixty-two patients initially diagnosed with breast cancer were recruited from the Department of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital. The psychological distress of the patients were assessed using the Beck Depression Inventory (BDI), the Montgomery-Asberg Depression Rating Scale (MADRS), the State-Trait Anxiety Inventory and their health-related quality of life was assessed with the Short Form 36-item Health Survey (SF-36). Statistical analyses were done using Spearman correlation and multiple linear regression analyses. Results：The total score of depressive symptom scales (BDI, MADRS) showed significant correlations with those of state anxiety and mental health component in the SF-36 Health Survey, respectively (BDI vs. state anxiety：r=0.578, p<0.001), (MADRS vs. state anxiety：r=0.505, p<0.001), (BDI vs. SF-36：r=-0.507, p=0.001), (MADRS vs. SF-36：r=-0.331, p= 0.042). In multiple linear regression analysis, mental health component score of the SF-36 was affected by BDI score. Conclusion：When breast cancer patients experienced depressive symptoms, they may suffer from anxiety and a poorer quality of mental health. Especially, subjective experience of depressive symptoms had significant negative impact on mental quality of life in breast cancer patients. Therefore, depressive symptoms need to be investigated and managed in breast cancer patients along with medical treatment.