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Effects of Body Composition, Leptin, and Adiponectin on Bone Mineral Density in Prepubertal Girls

Authors
 Young Jun Rhie  ;  Kee Hyoung Lee  ;  So Chung Chung  ;  Ho Seong Kim  ;  Duk Hee Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.25(8) : 1187-1190, 2010 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2010
MeSH
Absorptiometry, Photon ; Adiponectin/blood* ; Body Composition* ; Bone Density* ; Child ; Electric Impedance ; Female ; Humans ; Leptin/blood* ; Obesity/etiology
Keywords
Adiponectin ; Body Composition ; Bone Density ; Leptin ; Obesity
Abstract
Body weight is positively associated with bone mineral density but the relationship between obesity and bone mineral density is unclear. Leptin and adiponectin are potential independent contributors to bone mineral density. We assessed the correlations of body composition, leptin and adiponectin with bone mineral density, and whether leptin, adiponectin and body composition determine bone mineral density independently in prepubertal girls. Forty-eight prepubertal girls were classified into obese and control groups by body mass index. Serum leptin and adiponectin levels were determined by enzyme immunoassay. Bone mineral density was measured using dual energy radiography absorptiometry and body composition was measured using bioelectrical impedance analysis. Lean and fat mass, and leptin were positively correlated with bone mineral density. Lean mass was a positive independent predictor of femoral and L-spine bone mineral density. Serum leptin was a postivie independent predictor of femoral bone mineral density. Fat mass was a negative independent predictor of femoral bone mineral density. In prepubertal girls, lean mass has a favorable effect on bone mineral density. Fat mass seems not to protect the bone structure against osteoporosis, despite increased mechanical loading. Serum leptin may play a biological role in regulating bone metabolism.
Files in This Item:
T201005585.pdf Download
DOI
10.3346/jkms.2010.25.8.1187
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103154
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