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Prognostic factors in small cell lung cancer: a new prognostic index in Korean patients

DC FieldValueLanguage
dc.contributor.author김세규-
dc.contributor.author김주항-
dc.contributor.author박경수-
dc.contributor.author이수현-
dc.contributor.author정민규-
dc.contributor.author조병철-
dc.contributor.author최혜진-
dc.contributor.author홍수정-
dc.date.accessioned2015-04-23T17:47:33Z-
dc.date.available2015-04-23T17:47:33Z-
dc.date.issued2010-
dc.identifier.issn0030-2414-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103141-
dc.description.abstractOBJECTIVE: The aims of this study were to identify prognostic factors for overall survival (OS) in patients with small cell lung cancer (SCLC) and to construct a prognostic index on the basis of their expected OS. Long-term survivors were also given special attention. METHODS: We retrospectively analyzed 295 patients diagnosed with SCLC from January 2002 to September 2007 at the Severance Hospital, Seoul, Republic of Korea. Patient history was reviewed regarding both clinical and tumor-related markers, and treatment-related factors were also evaluated. RESULTS: There were 131 (44.4%) patients with limited disease (LD) and 164 (55.6%) with extensive disease (ED). Median follow-up lasted 9.4 months. Objective response to chemotherapy was 66.8%. The median survival time (MST) was 11.2 months in all patients, 20.4 months in LD patients, and 7.7 months in ED patients. The median progression-free survival was 9.4 months. Independent prognostic factors for overall survival (OS) were extent of disease, performance status, and CYFRA 21-1 level. We classified all patients into four groups based on the results of multivariate analysis using classification and regression tree analysis. Median survival times were 22.7, 13.7, 8.5, and 3.2 months, respectively. A total of 51 (17.3%) patients from the entire study population were evaluated for long-term survival, which was defined as survival >2 years. Their MST was 43.1 months, and extent of disease, performance status, and CYFRA 21-1 were independent prognostic factors for long-term survival. CONCLUSIONS: We confirmed the well-known prognosticators, disease extent and performance status, in our patients, but further identified CYFRA 21-1 as independent prognostic factor. A prognostic index was constructed to create four classifications of SCLC considering these variables-
dc.description.statementOfResponsibilityopen-
dc.format.extent293~300-
dc.relation.isPartOfOncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrognostic factors in small cell lung cancer: a new prognostic index in Korean patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHong S.-
dc.contributor.googleauthorCho B.C.-
dc.contributor.googleauthorChoi H.J.-
dc.contributor.googleauthorJung M.-
dc.contributor.googleauthorLee S.H.-
dc.contributor.googleauthorPark K.S.-
dc.contributor.googleauthorKim S.K.-
dc.contributor.googleauthorKim J.H.-
dc.identifier.doi10.1159/000323333-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00602-
dc.contributor.localIdA00945-
dc.contributor.localIdA01422-
dc.contributor.localIdA03606-
dc.contributor.localIdA03822-
dc.contributor.localIdA04219-
dc.contributor.localIdA04410-
dc.contributor.localIdA02898-
dc.relation.journalcodeJ02416-
dc.identifier.urlhttp://www.karger.com/Article/FullText/323333-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNamePark, Kyung Soo-
dc.contributor.alternativeNameLee, Soo Hyeon-
dc.contributor.alternativeNameJung, Min Kyu-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameChoi, Hye Jin-
dc.contributor.alternativeNameHong, Soo Jung-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorPark, Kyung Soo-
dc.contributor.affiliatedAuthorJung, Min Kyu-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorChoi, Hye Jin-
dc.contributor.affiliatedAuthorHong, Soo Jung-
dc.contributor.affiliatedAuthorLee, Soo Hyeon-
dc.citation.volume79-
dc.citation.number3-4-
dc.citation.startPage293-
dc.citation.endPage300-
dc.identifier.bibliographicCitationOncology, Vol.79(3-4) : 293-300, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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