Cited 151 times in
Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 박은성 | - |
dc.date.accessioned | 2015-04-23T17:46:07Z | - |
dc.date.available | 2015-04-23T17:46:07Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103094 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver cancers. The existence of combined hepatocellular-cholangiocarcinoma (CHC), a histopathologic intermediate form between HCC and CC, suggests phenotypic overlap between these tumors. Here, we applied an integrative oncogenomic approach to address the clinical and functional implications of the overlapping phenotype between these tumors. By performing gene expression profiling of human HCC, CHC, and CC, we identified a novel HCC subtype, i.e., cholangiocarcinoma-like HCC (CLHCC), which expressed cholangiocarcinoma-like traits (CC signature). Similar to CC and CHC, CLHCC showed an aggressive phenotype with shorter recurrence-free and overall survival. In addition, we found that CLHCC coexpressed embryonic stem cell-like expression traits (ES signature) suggesting its derivation from bipotent hepatic progenitor cells. By comparing the expression of CC signature with previous ES-like, hepatoblast-like, or proliferation-related traits, we observed that the prognostic value of the CC signatures was independent of the expression of those signatures. In conclusion, we suggest that the acquisition of cholangiocarcinoma-like expression traits plays a critical role in the heterogeneous progression of HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3034~3041 | - |
dc.relation.isPartOf | CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Carcinoma,Hepatocellular/metabolism* | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cholangiocarcinoma/metabolism* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | GeneExpressionProfiling | - |
dc.subject.MESH | GeneExpressionRegulation, Neoplastic* | - |
dc.subject.MESH | GeneRegulatory Networks | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Stem Cells/cytology | - |
dc.title | Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Medical Convergence (연의-생공연 메디컬융합연구소) | - |
dc.contributor.googleauthor | Hyun Goo Woo | - |
dc.contributor.googleauthor | Jeong-Hoon Lee | - |
dc.contributor.googleauthor | Jung-Hwan Yoon | - |
dc.contributor.googleauthor | Chung Yong Kim | - |
dc.contributor.googleauthor | Hyo-Suk Lee | - |
dc.contributor.googleauthor | Ja June Jang | - |
dc.contributor.googleauthor | Nam-Joon Yi | - |
dc.contributor.googleauthor | Kyung-Suk Suh | - |
dc.contributor.googleauthor | Kuhn Uk Lee | - |
dc.contributor.googleauthor | Eun Sung Park | - |
dc.contributor.googleauthor | Snorri S. Thorgeirsson | - |
dc.contributor.googleauthor | Yoon Jun Kim | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-09-2823 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01609 | - |
dc.relation.journalcode | J00452 | - |
dc.identifier.eissn | 1538-7445 | - |
dc.identifier.pmid | 20395200 | - |
dc.contributor.alternativeName | Park, Eun Sung | - |
dc.contributor.affiliatedAuthor | Park, Eun Sung | - |
dc.citation.volume | 70 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3034 | - |
dc.citation.endPage | 3041 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, Vol.70(8) : 3034-3041, 2010 | - |
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