Cited 94 times in
Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.date.accessioned | 2015-04-23T17:44:53Z | - |
dc.date.available | 2015-04-23T17:44:53Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103054 | - |
dc.description.abstract | Matrix metalloproteinase-9 (MMP-9) plays an important role in the invasion and metastasis of cancer cells. In this study, we examined the inhibitory effect of bee venom (BV) and its major peptides, melittin and apamin, on PMA-induced invasion induced by MMP-9 expression in Caki-1 renal cancer cells. BV and melittin, but not apamin, significantly suppressed PMA-induced invasion by inhibiting MMP-9 expression in Caki-1 cells. Furthermore, as evidenced by MMP-9 promoter assays, melittin inhibited MMP-9 gene expression by blocking the PMA-stimulated activations of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB). In addition, melittin suppressed the PMA-induced phosphorylations of ERK and JNK mitogen-activated protein kinases, upstream factors involved in Ap-1 and NF-kappaB. These results suggest that the suppression of MMP-9 expression contributes to the anti-tumor properties of melittin | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 209~215 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apamin/pharmacology | - |
dc.subject.MESH | CellLine,Tumor | - |
dc.subject.MESH | CellMovement/drug effects | - |
dc.subject.MESH | Drug Screening Assays, Antitumor | - |
dc.subject.MESH | Enzyme Activation/drug effects | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/metabolism | - |
dc.subject.MESH | GeneExpressionRegulation, Neoplastic/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.MESH | MAP Kinase Signaling System/drug effects | - |
dc.subject.MESH | Matrix Metalloproteinase 9/genetics | - |
dc.subject.MESH | Matrix Metalloproteinase 9/metabolism* | - |
dc.subject.MESH | Melitten/pharmacology* | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Neoplasm Invasiveness/pathology* | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Tetradecanoylphorbol Acetate | - |
dc.subject.MESH | Transcription Factor AP-1/metabolism* | - |
dc.title | Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Jung Hyun Park | - |
dc.contributor.googleauthor | Yun-Jeong Jeong | - |
dc.contributor.googleauthor | Kwan-Kyu Park | - |
dc.contributor.googleauthor | Hyun-Ji Cho | - |
dc.contributor.googleauthor | Il-Kyung Chung | - |
dc.contributor.googleauthor | Kwan-Sik Min | - |
dc.contributor.googleauthor | Mihyun Kim | - |
dc.contributor.googleauthor | Kwang-Gill Lee | - |
dc.contributor.googleauthor | Joo-Hong Yeo | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Young-Chae Chang | - |
dc.identifier.doi | 10.1007/s10059-010-0028-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01429 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 20082219 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10059-010-0028-9 | - |
dc.subject.keyword | bee venom | - |
dc.subject.keyword | Caki-1 renal carcinoma cells | - |
dc.subject.keyword | invasion | - |
dc.subject.keyword | melittin | - |
dc.subject.keyword | MMP-9 | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 209 | - |
dc.citation.endPage | 215 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, Vol.29(2) : 209-215, 2010 | - |
dc.identifier.rimsid | 35652 | - |
dc.type.rims | ART | - |
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