Cited 24 times in
Reductive degradation behavior of bioreducible poly(disulfide amine) for enhancing SiRNA efficiency
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김선화 | - |
dc.date.accessioned | 2015-04-23T17:44:15Z | - |
dc.date.available | 2015-04-23T17:44:15Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103033 | - |
dc.description.abstract | Bioreducible cationic polymer poly(CBA-DAH) containing repeated disulfide linkages on the polymer backbone was synthesized through Michael-type polyadditions of CBA to DAH monomers. Poly(CBA-DAH) could spontaneously form nanoscale polyelectrolyte complexes through electrostatic interactions with siRNA in an aqueous phase. These nanoparticles were rapidly degraded under the reductive cytoplasmic environment with subsequently releasing the siRNA cargo into the cytoplasm where RNAi takes place, as a result of the breakdown of disulfide bonds in the polymers. The reductive degradation behavior of the poly(CBA-DAH)/siRNA polyplexes is more likely to increase RNAi activity with enhancing the cytoplasmic localization of siRNA molecules. Poly(CBA-DAH) may have great potential as a gene carrier especially for therapeutic applications of siRNAs owing to the reductive degradation characteristics | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 898~905 | - |
dc.relation.isPartOf | MACROMOLECULAR BIOSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acrylic Resins/chemistry* | - |
dc.subject.MESH | Biocompatible Materials* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Disulfides/chemistry* | - |
dc.subject.MESH | Electrophoresis, Polyacrylamide Gel | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Spectroscopy | - |
dc.subject.MESH | Oxidation-Reduction | - |
dc.subject.MESH | RNA, Small Interfering/genetics* | - |
dc.subject.MESH | Transfection | - |
dc.title | Reductive degradation behavior of bioreducible poly(disulfide amine) for enhancing SiRNA efficiency | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Gomez-Manzano | - |
dc.identifier.doi | 10.1002/mabi.200900482 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00561 | - |
dc.relation.journalcode | J02176 | - |
dc.identifier.eissn | 1616-5195 | - |
dc.identifier.pmid | 20437407 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/mabi.200900482/abstract | - |
dc.subject.keyword | biodegradability | - |
dc.subject.keyword | bioreducible cationic polymer | - |
dc.subject.keyword | cytoplasmic localization | - |
dc.subject.keyword | nanoparticles | - |
dc.subject.keyword | polyelectrolyte complexes | - |
dc.subject.keyword | siRNA delivery | - |
dc.subject.keyword | polyelectrolytes | - |
dc.contributor.alternativeName | Kim, Sun Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Sun Hwa | - |
dc.citation.volume | 10 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 898 | - |
dc.citation.endPage | 905 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, Vol.10(8) : 898-905, 2010 | - |
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