Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement.

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Authors: Yeon Hong Lee ; Byung Koo Lee ; Yoon Jung Choi ; In Kyung Yoon ; Byung Chul Chang ; Hye Sun Gwak

MeSH: Cross-Over Studies ; Double-Blind Method ; Female ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation* ; Herb-Drug Interactions/physiology* ; Humans ; International Normalized Ratio ; Male ; Middle Aged ; Panax/metabolism* ; Plant Extracts/blood* ; Plant Extracts/therapeutic use ; Prospective Studies ; Warfarin/blood* ; Warfarin/therapeutic use

Abstract: BACKGROUND: The objective of this study was to determine whether an interaction exists between warfarin and Korean red ginseng.

METHODS: A prospective, double-blind, randomized, two-period crossover study was conducted on 25 patients with cardiac valve replacement under warfarin therapy. Either Korean red ginseng 1 g or placebo (hop extract 0.25 g, caramel color 0.05 g, and red ginseng flavor 0.03 g) was concomitantly administered with warfarin. INR and warfarin concentrations were analyzed on the 3rd and 6th weeks of each study period.

RESULTS: The INR changes on the 3rd and 6th weeks of Korean red ginseng administration were -0.16±0.95 and -0.14±0.94 whereas those of placebo were -0.03±0.65 and 0.25±0.95; there were no statistically significant differences in mean INR changes.

CONCLUSION: Korean red ginseng could be used with close monitoring and under appropriate education in patients who take warfarin.

Full Text: http://www.sciencedirect.com/science/article/pii/S0167527309014995

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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