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Factors related to clinically probable REM sleep behavior disorder in Parkinson disease

Authors
 Ji E. Lee  ;  Kyung S. Kim  ;  Hae-Won Shin  ;  Young H. Sohn 
Citation
 PARKINSONISM & RELATED DISORDERS, Vol.16(2) : 105-108, 2010 
Journal Title
PARKINSONISM & RELATED DISORDERS
ISSN
 1353-8020 
Issue Date
2010
MeSH
Aged ; Female ; Humans ; Logistic Models ; Male ; Mental Status Schedule ; Middle Aged ; Odds Ratio ; Parkinson Disease/complications* ; Parkinson Disease/epidemiology ; Polysomnography ; REM Sleep Behavior Disorder/complications* ; REM Sleep Behavior Disorder/epidemiology ; Severity of Illness Index
Abstract
Rapid eye movement sleep behavior disorder (RBD) is commonly accompanied in Parkinson disease (PD). However, the underlying mechanism linking RBD to PD remains unclear. We interviewed and examined 447 consecutive patients with PD to investigate factors associated with the presence of RBD in PD patients. Using the minimal diagnostic criteria for parasomnias provided in the International Classification of Sleep Disorders-Revised (ICSD-R), 164 patients (36.5%) were diagnosed with clinically probable RBD (cpRBD). PD patients with cpRBD were older, had a longer duration of PD, a more severe level of disability, a longer duration of antiparkinsonian medication, and a lower proportion of their Unified Parkinson Disease Rating Scale (UPDRS) scores accounted for by tremor than those without RBD. Multivariate and univariate logistic regression analyses revealed that patient age, PD symptom duration (and, accordingly, more severe motor disability), tremor score, and proportion of the UPDRS score accounted for by tremor were significant factors associated with the presence of RBD in PD patients. The results of the present study support previous observations that PD with RBD may result from a different underlying pattern of neurodegeneration than PD without RBD
Full Text
http://www.sciencedirect.com/science/article/pii/S1353802009002144
DOI
10.1016/j.parkreldis.2009.08.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102986
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