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Association of Renal Manifestations with Serum Uric Acid in Korean Adults with Normal Uric Acid Levels

DC FieldValueLanguage
dc.contributor.author심재용-
dc.contributor.author이용제-
dc.contributor.author이혜리-
dc.contributor.author정동혁-
dc.date.accessioned2015-04-23T17:42:16Z-
dc.date.available2015-04-23T17:42:16Z-
dc.date.issued2010-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102969-
dc.description.abstractSeveral studies have reported that hyperuricemia is associated with the development of hypertension and cardiovascular disease. Increasing evidences also suggest that hyperuricemia may have a pathogenic role in the progression of renal disease. Paradoxically, uric acid is also widely accepted to have antioxidant activity in experimental studies. We aimed to investigate the association between glomerular filtration rate (GFR) and uric acid in healthy individuals with a normal serum level of uric acid. We examined renal function determined by GFR and uric acid in 3,376 subjects (1,896 men; 1,480 women; aged 20-80 yr) who underwent medical examinations at Gangnam Severance Hospital from November 2006 to June 2007. Determinants for renal function and uric acid levels were also investigated. In both men and women, GFR was negatively correlated with systolic and diastolic blood pressures, fasting plasma glucose, total cholesterol, uric acid, log transformed C reactive protein, and log transformed triglycerides. In multivariate regression analysis, total uric acid was found to be an independent factor associated with estimated GFR in both men and women. This result suggests that uric acid appears to contribute to renal impairment in subjects with normal serum level of uric acid.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1766~1770-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBlood Glucose/analysis-
dc.subject.MESHBlood Pressure-
dc.subject.MESHCholesterol/blood-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHumans-
dc.subject.MESHHyperuricemia/blood-
dc.subject.MESHHyperuricemia/etiology-
dc.subject.MESHKidney Diseases/blood*-
dc.subject.MESHKidney Diseases/etiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRegression Analysis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHUric Acid/blood*-
dc.titleAssociation of Renal Manifestations with Serum Uric Acid in Korean Adults with Normal Uric Acid Levels-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorDong-Hyuk Jung-
dc.contributor.googleauthorYong-Jae Lee-
dc.contributor.googleauthorHye-Ree Lee-
dc.contributor.googleauthorJung-Hyun Lee-
dc.contributor.googleauthorJae-Yong Shim-
dc.identifier.doi10.3346/jkms.2010.25.12.1766-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02207-
dc.contributor.localIdA02982-
dc.contributor.localIdA03595-
dc.contributor.localIdA03310-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid21165292-
dc.subject.keywordAntioxidants-
dc.subject.keywordGlomerular Filtration Rate-
dc.subject.keywordUric Acid-
dc.contributor.alternativeNameShim, Jae Yong-
dc.contributor.alternativeNameLee, Yong Jae-
dc.contributor.alternativeNameLee, Hye Ree-
dc.contributor.alternativeNameJung, Dong Hyuk-
dc.contributor.affiliatedAuthorShim, Jae Yong-
dc.contributor.affiliatedAuthorLee, Yong Jae-
dc.contributor.affiliatedAuthorJung, Dong Hyuk-
dc.contributor.affiliatedAuthorLee, Hye Ree-
dc.citation.volume25-
dc.citation.number12-
dc.citation.startPage1766-
dc.citation.endPage1770-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.25(12) : 1766-1770, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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