Treatment outcome of localized Helicobacter pylori-negative low-grade gastric MALT lymphoma.

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Authors: Hyung Soon Park ; Yu Jin Kim ; Woo Ick Yang ; Chang Ok Suh ; Yong Chan Lee

MeSH: Adult ; Aged ; Female ; Helicobacter pylori/isolation & purification ; Humans ; Lymphoma, B-Cell, Marginal Zone/microbiology ; Lymphoma, B-Cell, Marginal Zone/pathology ; Lymphoma, B-Cell, Marginal Zone/therapy* ; Male ; Middle Aged ; Retrospective Studies ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy* ; Treatment Outcome

Abstract: AIM: To investigate treatment outcome of Helicobacter pylori (H. pylori)-negative low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma.

METHODS: In this study, we retrospectively reviewed the clinical outcome and clinicopathologic factors of stage IE H. pylori-negative low-grade gastric MALT lymphoma cases from August 1998 to June 2009.

RESULTS: A total of eleven patients with H. pylori-negative low-grade gastric MALT lymphoma were enrolled in the study and received anti-H. pylori eradication treatment and/or radiotherapy or excisional therapy. Complete remission (CR) of gastric MALT lymphoma was achieved in all patients. The time to CR was 1-66 mo (median, 1 mo).

CONCLUSION: Eradication therapy may be offered as an initial treatment option even in cases of localized H. pylori-negative gastric MALT lymphoma.