Cited 13 times in
Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo
DC Field | Value | Language |
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dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2015-04-23T17:36:09Z | - |
dc.date.available | 2015-04-23T17:36:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1359-6535 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102776 | - |
dc.description.abstract | BACKGROUND: Respiratory enteric orphan (reo)virus is a promising oncolytic viral candidate. Reoviral anticancer therapy is currently undergoing multiple clinical trials targeting various human cancers; however, there is no effective reoviral inhibitor that can be used to block unwanted reovirus replication during reoviral anticancer therapy. METHODS: Studies were conducted with transformed or normal cells in vitro and in vivo to characterize viral replication in the presence or absence of chemical inhibitors. RESULTS: We have identified a protease inhibitor that is very effective in the inhibition of viral replication. The dipeptide benzyloxycarbonyl-Phe-Ala-fluoromethyl ketone (Z-FA-FMK) effectively inhibited reovirus replication in a susceptible host and cured cells of a persistent infection with reovirus in vitro. Electron microscopic analysis of Z-FA-FMK-treated cells revealed that internalized reovirus virions, retained in a perinuclear localization, no longer undergo further processing into viral factories following Z-FA-FMK treatment, suggesting that Z-FA-FMK specifically affects a reovirus virion maturation step. Animal studies showed that reovirus infection of Ras oncogenic tumours and host heart tissues is completely blocked by Z-FA-FMK treatment in severe combined immunodeficiency mice. CONCLUSIONS: Z-FA-FMK is a very effective viral inhibitor that can prevent reovirus replication in vitro and reovirus-mediated myocarditis, as well as reovirus-mediated oncolysis, in vivo. A potential application of this drug for inhibition of reovirus infection is suggested | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 897~905 | - |
dc.relation.isPartOf | ANTIVIRAL THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antiviral Agents/therapeutic use | - |
dc.subject.MESH | Capsid/drug effects | - |
dc.subject.MESH | Capsid/physiology | - |
dc.subject.MESH | Capsid/virology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cysteine Proteinase Inhibitors/therapeutic use* | - |
dc.subject.MESH | Dipeptides/therapeutic use* | - |
dc.subject.MESH | Genes, ras | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ketones/therapeutic use* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, SCID | - |
dc.subject.MESH | Oncolytic Viruses/drug effects* | - |
dc.subject.MESH | Oncolytic Viruses/pathogenicity | - |
dc.subject.MESH | Reoviridae/drug effects* | - |
dc.subject.MESH | Reoviridae/pathogenicity | - |
dc.subject.MESH | Reoviridae/physiology | - |
dc.subject.MESH | Reoviridae Infections/therapy* | - |
dc.subject.MESH | Virus Replication/drug effects | - |
dc.title | Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Cancer Research (암연구소) | - |
dc.contributor.googleauthor | Manbok Kim | - |
dc.contributor.googleauthor | Kristina K Hansen | - |
dc.contributor.googleauthor | Lesley Davis | - |
dc.contributor.googleauthor | Guido van Marle | - |
dc.contributor.googleauthor | Michael John Gill | - |
dc.contributor.googleauthor | Julie D Fox | - |
dc.contributor.googleauthor | Morley D Hollenberg | - |
dc.contributor.googleauthor | Derrick E Rancourt | - |
dc.contributor.googleauthor | Patrick WK Lee | - |
dc.contributor.googleauthor | Chae-Ok Yun | - |
dc.contributor.googleauthor | Randal N Johnston | - |
dc.identifier.doi | 10.3851/IMP1646 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02614 | - |
dc.relation.journalcode | J00191 | - |
dc.identifier.eissn | 2040-2058 | - |
dc.identifier.pmid | 20834102 | - |
dc.identifier.url | http://www.intmedpress.com/journals/avt/article.cfm?id=1646&pid=88&sType=AVT | - |
dc.contributor.alternativeName | Yun, Chae Ok | - |
dc.contributor.affiliatedAuthor | Yun, Chae Ok | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 897 | - |
dc.citation.endPage | 905 | - |
dc.identifier.bibliographicCitation | ANTIVIRAL THERAPY, Vol.15(6) : 897-905, 2010 | - |
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