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Outcome of adjuvant therapy for gallbladder cancer

Authors
 Park H.S.  ;  Lim J.Y.  ;  Yoon D.S.  ;  Park J.S.  ;  Lee D.K.  ;  Lee S.J.  ;  Choi H.J.  ;  Song S.Y.  ;  Lee W.J.  ;  Cho J.Y. 
Citation
 ONCOLOGY, Vol.79(3-4) : 168-173, 2010 
Journal Title
 ONCOLOGY 
ISSN
 0030-2414 
Issue Date
2010
MeSH
Adenocarcinoma/therapy* ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use* ; Carcinoma, Adenosquamous/therapy* ; Carcinoma, Squamous Cell/therapy* ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Female ; Gallbladder Neoplasms/therapy* ; Humans ; Male ; Middle Aged ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Rate ; Treatment Outcome
Keywords
Adjuvant ; Chemotherapy ; Gallbladder carcinoma ; Radiotherapy
Abstract
OBJECTIVES: The aim of this study was to evaluate the outcome of adjuvant therapy on the overall survival (OS) and disease-free survival (DFS) after curative resection (RO) of patients with TNM stage II gallbladder (GB) cancer. METHODS: A total of 160 patients who had received curative resection (RO) between January 2000 and December 2009 were retrospectively reviewed. Among 61 stage II GB cancer patients, 43 received adjuvant therapy, while 18 others received surgery alone. The median follow-up period was 27.3 months (range 2.2-98.9 months). RESULTS: OS was not significantly different among the adjuvant therapies (p = 0.180), but DFS was (p = 0.033). The 3-year OS and DFS from surgery alone, adjuvant chemotherapy, adjuvant radiotherapy, and adjuvant concurrent chemo-radiotherapy were 64, 78, 36 and 36%, and 56, 69, 14 and 47%, respectively. Overall, the chemotherapy group had a better prognosis, although there were no significant differences. CONCLUSIONS: The data from this study do not provide evidence that adjuvant therapy is an effective treatment option for curative resected GB cancer. A large randomized controlled study is necessary to confirm the efficacy of adjuvant therapy. Newer adjuvant studies should be focused on gemcitabine-based chemotherapy or chemo-radiotherapy with molecular-based target agents
Full Text
http://www.karger.com/Article/FullText/322914
DOI
10.1159/000322914
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Joon Seong(박준성) ORCID logo https://orcid.org/0000-0001-8048-9990
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
Lee, Dong Ki(이동기) ORCID logo https://orcid.org/0000-0002-0048-9112
Lee, Se Joon(이세준) ORCID logo https://orcid.org/0000-0002-2695-2670
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Lim, Jae Yun(임재윤)
Cho, Jae Yong(조재용) ORCID logo https://orcid.org/0000-0002-0926-1819
Choi, Hye Jin(최혜진) ORCID logo https://orcid.org/0000-0001-5917-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102718
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