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Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes

Authors
 Jérémy Ricci  ;  Jeehyun Park  ;  Won-Yoon Chung  ;  Kwang-Kyun Park  ;  Mankil Jung 
Citation
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.20(22) : 6858-6860, 2010 
Journal Title
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 
ISSN
 0960-894X 
Issue Date
2010
MeSH
Angiogenesis Inhibitors/chemical synthesis* ; Angiogenesis Inhibitors/pharmacology* ; Animals ; Artemisinins/chemistry* ; Chick Embryo ; Chorion/drug effects* ; Glycolipids/chemistry*
Abstract
Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.
Full Text
http://www.sciencedirect.com/science/article/pii/S0960894X10011236
DOI
10.1016/j.bmcl.2010.08.013
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102681
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