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Shared neural activity in panic disorder and undifferentiated somatoform disorder compared with healthy controls.

 Kyung Bong Koh  ;  Jee In Kang  ;  Jong Doo Lee  ;  Young-joon Lee 
 JOURNAL OF CLINICAL PSYCHIATRY, Vol.71(12) : 1576-1581, 2010 
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Adult ; Case-Control Studies ; Cerebral Cortex/blood supply* ; Cerebral Cortex/diagnostic imaging ; Cerebrovascular Circulation* ; Cysteine/analogs & derivatives ; Female ; Frontal Lobe/blood supply ; Functional Laterality ; Humans ; Image Processing, Computer-Assisted ; Korea ; Male ; Occipital Lobe/blood supply ; Organotechnetium Compounds ; Panic Disorder/diagnostic imaging ; Panic Disorder/physiopathology* ; Parahippocampal Gyrus/blood supply ; Parietal Lobe/blood supply ; Radiopharmaceuticals ; Somatoform Disorders/diagnostic imaging ; Somatoform Disorders/physiopathology* ; Temporal Lobe/blood supply ; Tomography, Emission-Computed, Single-Photon*
OBJECTIVE: In previous studies, some brain areas, including parahippocampal gyrus, were suggested to be associated with panic disorder. Both panic disorder and somatoform disorders are associated with anxiety. This study sought to determine if there are shared neural activity underlying panic disorder and undifferentiated somatoform disorder. METHOD: Sixteen nonmedicated patients with panic disorder, 16 nonmedicated patients with undifferentiated somatoform disorder, and 10 healthy subjects were scanned between February 2005 and August 2006. Diagnoses were made according to the Korean version of the Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Patient/Non-Patient Edition. Regional cerebral perfusion was measured by 99 m-Tc-ethyl cysteinate dimer single photon emission computed tomography (SPECT). Using statistical parametric mapping analysis, we compared the SPECT images between the groups. RESULTS: Significant hyperperfusion was found at the left superior temporal gyrus and the left supramarginal gyrus in the panic disorder patients when compared to the controls (family-wise error [FWE], P < .001). The somatoform disorder patients showed hyperperfusion in the left hemisphere at the superior temporal gyrus, inferior parietal lobule, middle occipital gyrus, precentral gyrus, postcentral gyrus, and, in the right hemisphere, at the superior temporal gyrus when compared to the controls (false discovery rate [FDR], P < .001). In contrast, significant hypoperfusion was found at the right parahippocampal gyrus in each of panic disorder (FWE, P = .001) and somatoform disorder (FWE, P < .001) groups compared to healthy controls. However, no significant differences were found in regional cerebral perfusion between the 2 disorder groups. CONCLUSIONS: Both panic disorder and undifferentiated somatoform disorder showed hyperperfusion in the left superior temporal gyrus and hypoperfusion in the right parahippocampal gyrus, which suggests that the 2 disorders are likely to share neural activity
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Koh, Kyung Bong(고경봉)
Lee, Youngjoon(이영준) ORCID logo https://orcid.org/0000-0002-9602-5186
Lee, Jong Doo(이종두)
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