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Dietary conjugated linoleic acid increases endurance capacity of mice during treadmill exercise

Authors
 Jun Ho Kim  ;  Hui Gyu Park  ;  Jung Hoon Pan  ;  Sang Ho Kim  ;  Ho Geun Yoon  ;  Gui Seck Bae  ;  Hyungjae Lee  ;  Seok-Hyun Eom  ;  Young Jun Kim 
Citation
 JOURNAL OF MEDICINAL FOOD, Vol.13(5) : 1057-1060, 2010 
Journal Title
 JOURNAL OF MEDICINAL FOOD 
ISSN
 1096-620X 
Issue Date
2010
MeSH
Animals ; Blood Urea Nitrogen ; Dietary Fats, Unsaturated/pharmacology* ; Energy Metabolism ; Fatty Acids, Nonesterified/blood ; Glycogen/metabolism ; Linoleic Acids, Conjugated/blood ; Linoleic Acids, Conjugated/pharmacology* ; Liver/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Physical Endurance/drug effects* ; Physical Exertion ; Triglycerides/blood
Abstract
This study was designed to evaluate the effect of dietary conjugated linoleic acid (CLA) on endurance exercise and availability of metabolic substrates in mice. Four-week-old male BALB/c mice were randomized to a control group (normal diet) and a CLA group (normal diet + 1% CLA). Each animal group received its respective diet for 10 weeks and was subjected to forced running on a treadmill system to estimate their maximum endurance capacity at the end of the experiment. All mice were immediately sacrificed after prolonged exercise, and the major metabolic substrates were measured in serum and liver. The body weights of mice in the CLA group were lower than those of the control group after the 10 weeks. The maximum running time in CLA-fed mice was significantly longer, by 26%, compared to that of the control mice. Dietary CLA decreased the serum concentrations of triglycerides, nonesterified fatty acids, and urea nitrogen and significantly reduced the consumption of liver glycogen. The present study demonstrated that dietary CLA enhances the endurance capacity of mice by increasing fat utilization and reducing the consumption of stored liver glycogen as substrates for energy metabolism.
Full Text
http://online.liebertpub.com/doi/abs/10.1089/jmf.2009.1358
DOI
10.1089/jmf.2009.1358
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102633
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