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Alagebrium chloride, a novel advanced glycation end-product cross linkage breaker, inhibits neointimal proliferation in a diabetic rat carotid balloon injury model.
DC Field | Value | Language |
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dc.contributor.author | 이현철 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 황기철 | - |
dc.contributor.author | 김진배 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 송병욱 | - |
dc.contributor.author | 이문형 | - |
dc.date.accessioned | 2015-04-23T17:30:37Z | - |
dc.date.available | 2015-04-23T17:30:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102603 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Vascular perturbation induced by advanced glycation end-products (AGEs) leads to progression of atherosclerosis, plaque instability, and vascular inflammation, which results in a higher risk of neointimal proliferation. Here we investigated the inhibitory effect of alagebrium chloride (ALT-711), a breaker of AGE-based cross links, on neointimal proliferation in a carotid artery balloon injury model in diabetic rats induced by streptozotocin (STZ). MATERIALS AND METHODS: Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 µM of alagebrium added 24 hours before the addition of AGEs. This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ. Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced. After 4 weeks, the animals were sacrificed for histological analysis. RESULTS: Proliferation of RASMCs was significantly inhibited in alagebrium-treated cells. Alagebrium dose-dependently inhibited AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression. The cellular mechanisms of AGE-induced connective tissue and extracellular matrix expression were decreased in the alagebrium-treated group. This in vivo study shows that expression of AGE receptors and neointima hyperplasia are significantly suppressed in balloon-injured rats treated with alagebrium. CONCLUSION: Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 520~526 | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Alagebrium chloride, a novel advanced glycation end-product cross linkage breaker, inhibits neointimal proliferation in a diabetic rat carotid balloon injury model. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jin-Bae Kim | - |
dc.contributor.googleauthor | Byeong-Wook Song | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Bong-Soo Cha | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Hyun-Chul Lee | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.identifier.doi | 10.4070 / kcj.2010.40.10.520 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04456 | - |
dc.contributor.localId | A01016 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02026 | - |
dc.contributor.localId | A02766 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 21088756 | - |
dc.subject.keyword | Advanced glycation end-products | - |
dc.subject.keyword | Alagebrium | - |
dc.subject.keyword | Neointimal hyperplasia | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.alternativeName | Kim, Jin Bae | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Song, Byeong Wook | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Kim, Jin Bae | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Song, Byeong Wook | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.citation.volume | 40 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 520 | - |
dc.citation.endPage | 526 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.40(10) : 520-526, 2010 | - |
dc.identifier.rimsid | 55320 | - |
dc.type.rims | ART | - |
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