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Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease

Authors
 J.E. Lee  ;  H.-J. Park  ;  S.K. Song  ;  Y.H. Sohn  ;  J.D. Lee  ;  P.H. Lee 
Citation
 NEUROLOGY, Vol.75(22) : 2009-2016, 2010 
Journal Title
 NEUROLOGY 
ISSN
 0028-3878 
Issue Date
2010
MeSH
Aged ; Atrophy/pathology ; Atrophy/physiopathology ; Brain/pathology* ; Brain/physiopathology ; Brain Mapping ; Cognition Disorders/complications* ; Cognition Disorders/pathology* ; Cognition Disorders/physiopathology ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Memory Disorders/complications* ; Memory Disorders/pathology* ; Memory Disorders/physiopathology ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease/complications* ; Parkinson Disease/pathology* ; Parkinson Disease/physiopathology
Keywords
All Cognitive Disorders/Dementia ; MRI ; Parkinson's disease/Parkinsonism ; MCI (mild cognitive impairment)
Abstract
OBJECTIVE: To explore the neuroanatomic basis of amnestic mild cognitive impairment (aMCI) in patients with Parkinson disease (PD; aMCI-PD(+)) and without PD (aMCI-PD(-)). METHODS: A total of 119 patients with aMCI (aMCI-PD(-), n = 78, and aMCI-PD(+), n = 41) underwent T1-weighted MRI, and the image data were analyzed using voxel-based morphometry. RESULTS: No significant differences in demographic characteristics or general cognition were found between patients with aMCI-PD(-) and aMCI-PD(+). Comparisons of neuropsychological tests between groups revealed that patients with aMCI-PD(-) had lower scores in delayed verbal and visual recognition memory, whereas visuospatial dysfunction was more severe in patients with aMCI-PD(+). Gray matter (GM) density in the right temporal and posterior cingular cortices was significantly lower in the aMCI-PD(-) group compared with controls. In contrast, GM density in the aMCI-PD(+) group was significantly lower in the precuneus and left prefrontal and primary motor areas relative to controls. A direct comparison between groups showed that decreased GM density in aMCI-PD(-) relative to aMCI-PD(+) was localized in the right temporal and anterior prefrontal areas, whereas decreased GM density in aMCI-PD(+) relative to aMCI-PD(-) was involved in the bilateral precuneus, left primary motor, and right parietal areas. Memory decline was correlated with temporal area atrophy in aMCI-PD(-) and with posterior cingulate cortex atrophy in aMCI-PD(+). CONCLUSIONS: Our data suggest that different neuroanatomic systems underlie memory dysfunction in patients with aMCI-PD(-) and aMCI-PD(+).
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006114-201011300-00013&LSLINK=80&D=ovft
DOI
10.1212/WNL.0b013e3181ff96bf
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Jong Doo(이종두)
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102531
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