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Bugs and irritable bowel syndrome: The good, the bad and the ugly.

Authors
 Uday C Ghoshal  ;  Hyojin Park  ;  Kok-Ann Gwee 
Citation
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.25(2) : 244-251, 2010 
Journal Title
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 
ISSN
 0815-9319 
Issue Date
2010
MeSH
Anti-Bacterial Agents/therapeutic use* ; Asian Continental Ancestry Group ; Bacterial Infections/ethnology ; Bacterial Infections/microbiology* ; Bacterial Infections/therapy ; Evidence-Based Medicine ; Gastrointestinal Tract/microbiology* ; Gastrointestinal Tract/parasitology ; Helminthiasis/ethnology ; Helminthiasis/parasitology ; Humans ; Intestinal Diseases, Parasitic/ethnology ; Intestinal Diseases, Parasitic/parasitology ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/ethnology ; Irritable Bowel Syndrome/microbiology* ; Irritable Bowel Syndrome/parasitology ; Irritable Bowel Syndrome/therapy ; Probiotics/therapeutic use* ; Risk Factors
Keywords
functional bowel disease ; gastrointestinal infection ; gut flora ; post‐infective irritable bowel syndrome ; probiotics ; small intestinal bacterial overgrowth
Abstract
Recently, there has been strong interest in the therapeutic potential of probiotics for irritable bowel syndrome (IBS). At the same time, there is a rapidly growing body of evidence to support an etiological role for gastrointestinal infection and the associated immune activation in the development of post-infectious IBS. In a more controversial area, small intestinal bacterial overgrowth has been associated with a subset of patients with IBS; the issue of whether it is appropriate to treat a subset of IBS patients with antibiotics and probiotics is currently a matter for debate. Thus, it appears that the gastrointestinal microbial flora may exert beneficial effects for symptoms of IBS under some circumstances, while in other situations gut microbes could give rise to symptoms of IBS. How do we make sense of the apparently diverse roles that 'bugs' may play in IBS? To address this question, we have conducted an in-depth review, attempting where possible to draw lessons from Asian studies
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2009.06133.x/abstract
DOI
10.1111/j.1440-1746.2009.06133.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102480
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