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Visceral adiposity and the severity of coronary artery disease in middle-aged subjects with normal waist circumference and its relation with lipocalin-2 and MCP-1.

Authors
 Yong-ho Lee  ;  Sang-Hak Lee  ;  Eun Suk Jung  ;  Jung-Sun Kim  ;  Chi Young Shim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Namsik Chung  ;  Jong-Won Ha 
Citation
 ATHEROSCLEROSIS, Vol.213(12) : 592-597, 2010 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2010
MeSH
Adult ; Chemokine CCL2/blood* ; Coronary Artery Disease/pathology* ; Humans ; Intra-Abdominal Fat/diagnostic imaging* ; Lipocalins/blood* ; Male ; Middle Aged ; Tomography, X-Ray Computed ; Waist Circumference*
Keywords
Visceral fat ; Waist circumference ; Coronary disease ; Adipokine
Abstract
OBJECTIVE: Visceral adipose tissue has emerged as a key organ contributing to the development of coronary artery disease (CAD). However, defining central obesity by waist circumference (WC) may underestimate visceral adiposity in lean patients. The aim of this study was to investigate the relationship between visceral adiposity and severity of CAD in subjects with normal WC. METHODS: Among 365 patients with documented CAD, 90 male subjects with normal WC (<90 cm) were selected and their visceral fat areas (VFA) were examined using computed tomography. Lipid profiles and levels of adipokines including lipocalin-2, high molecular weight adiponectin, and monocyte chemoattractant protein (MCP)-1 were measured. Patients were divided into tertiles based on VFA at the L4 vertebra level. RESULTS: Patients with single-vessel disease had significantly lower VFA than those with multi-vessel disease (P<0.05; 86.0 vs. 97.5 vs. 99.6 cm(2) for single- , double- , and triple-vessel diseases, respectively). Positive association between the extent of CAD and VFA was clearly demonstrated and logistic regression analysis showed that subjects in the upper tertile for VFA had a 4.5-fold higher risk of having multi-vessel disease compared with those in the lowest tertile (P<0.05; odds ratio=4.51; 95% confidence interval=1.10-18.45). Circulating levels of lipocalin-2 and MCP-1 were significantly higher in the upper tertiles of VFA. CONCLUSION: Increased visceral adiposity is significantly associated with the severity of CAD, even in subjects without central obesity as determined by WC measurements. Abnormalities in adipokine regulation may provide a novel mechanistic connection between visceral adiposity and associated cardiovascular complications.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915010007409
DOI
10.1016/j.atherosclerosis.2010.09.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Jung, Eun Suk(정은석)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102473
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