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Gender differences in clinical features and in-hospital outcomes in ST-segment elevation acute myocardial infarction: from the Korean Acute Myocardial Infarction Registry (KAMIR) study

Authors
 Jong-Seon Park  ;  Young-Jo Kim  ;  Dong-Gu Shin  ;  Myung-Ho Jeong  ;  Young-Keun Ahn  ;  Wook-Sung Chung  ;  Ki-Bae Seung  ;  Chong-Jin Kim  ;  Myeong-Chan Cho  ;  Yang-Soo Jang  ;  Seung-Jung Park  ;  In-Whan Seong  ;  Shung-Chull Chae  ;  Seung-Ho Hur  ;  Dong-Hoon Choi  ;  Taek-Jong Hong 
Citation
 CLINICAL CARDIOLOGY, Vol.33(8) : 1-6, 2010 
Journal Title
 CLINICAL CARDIOLOGY 
ISSN
 0160-9289 
Issue Date
2010
MeSH
Aged ; Aged, 80 and over ; Chi-Square Distribution ; Coronary Angiography ; Female ; Health Status Disparities* ; Healthcare Disparities* ; Hospital Mortality ; Humans ; Inpatients* ; Logistic Models ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/mortality ; Myocardial Infarction/therapy* ; Myocardial Reperfusion*/adverse effects ; Myocardial Reperfusion*/mortality ; Prospective Studies ; Recurrence ; Registries ; Republic of Korea ; Risk Assessment ; Risk Factors ; Sex Factors ; Stroke/etiology ; Time Factors ; Treatment Outcome
Abstract
BACKGROUND: Studies have suggested that women are biologically different and that female gender itself is independently associated with poor clinical outcome after an acute myocardial infarction (AMI). HYPOTHESIS: We analyzed data from the Korean Acute Myocardial Infarction Registry (KAMIR) to assess gender differences in in-hospital outcomes post ST-segment elevation myocardial infarction (STEMI). METHODS: Between November 2005 and July 2007, 4037 patients who were admitted with STEMI to 41 facilities were registered into the KAMIR database; patients admitted within 72 hours of symptom onset were selected and included in this study. RESULTS: The proportion of patients who had reperfusion therapy within 12 hours from chest pain onset was lower in women. Women had higher rates of in-hospital mortality (8.6% vs 3.2%, P < .01), noncardiac death (1.5% vs 0.4%, P < .01), cardiac death (7.1% vs 2.8%, P < .01), and stroke (1.2% vs 0.5%, P < .05) than men. Multivariate logistic regression analysis identified age, previous angina, hypertension, a Killip class > or = II, a left ventricular ejection fraction (LVEF) < 40%, and a thrombolysis in myocardial infarction flow (TIMI) grade < or = 3 after angioplasty as independent risk factors for in-hospital death for all patients; however, female gender itself was not an independent risk factor. CONCLUSIONS: The results of this study show that although women have a higher in-hospital mortality than men, female gender itself is not an independent risk factor for in-hospital mortality.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/clc.20557/abstract
DOI
10.1002/clc.20557
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102464
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