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Respiratory Syncytial Virus 재감염에 의한 기도과민성과 기도염증에 대한 Cytosine-phosphate-Guanine oligodeoxynucleotides의 효과

Other Titles
 Effect of Cytosine-phosphate-Guanine Oligodeoxynucleotides on Airway Hyperresponsiveness and Inflammation of Repeated Respiratory Syncytial Virus Infection in a Mouse Model 
Authors
 장광천  ;  이용원  ;  김규언  ;  홍천수  ;  박중원 
Citation
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.30(2) : 123-130, 2010 
Journal Title
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) 
ISSN
 1226-8739 
Issue Date
2010
Keywords
RSV ; Airway function ; Animal model ; CpG ODNs
Abstract
Background: Severe respiratory syncytial virus (RSV) infection in neonate has been reported as a risk factor for the development of allergic asthma or early transient wheezing. RSV can induce reinfection by the same strain. Reinfection after neonatal RSV infection can induce eosinophilic inflammation and aggravate airway hyperresponsiveness (AHR) in a BALB/C mouse model. Objective: We evaluated whether cytosine-phosphate- guanine oligodeoxynucleotides (CpG ODNs) administration at initial RSV infection could prevent the aggravation of AHR and eosinophilic inflammation with repeated RSV infection in a mouse model. Method: Mice were infected shortly after birth and were reinfected 5 weeks later by the intranasal administration of RSV (106 pfu) and followed by the assessment of airway function, airway inflammation, and lung histopathology. Phosphorothioate CpG (1,826s; 2 mcg/mouse) was also administered intranasally 2 days after initial RSV infection. Result: Repeated RSV infection induced methacholine (Mch) AHR, eosinophilic inflammation and goblet cell hyperplasia in the control ODN group. CpG ODN administration at initial RSV infection attenuated Mch AHR and eosinophilic inflammation, and decreased levels of IL-13 and IL-5, but increased IFN-γ in BAL fluid and RSV- IgG2a in sera. Conclusion: These findings suggest that CpG ODN can be used to prevent of airway allergic inflammation by RSV reinfection
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Lee, Yong Won(이용원)
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102430
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