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Lipo-PGE1이 이식된 지방 생존에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 유대현 | - |
dc.date.accessioned | 2015-04-23T17:23:59Z | - |
dc.date.available | 2015-04-23T17:23:59Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1015-6402 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102388 | - |
dc.description.abstract | PURPOSE: With the recent recognition of the importance of soft-tissue fillers, fat grafting has been assumed an increasingly important role as both an adjunctive and a primary procedure in aesthetic and reconstructive surgery. The main problem in achieving long-term soft-tissue augmentation is partial absorption of the injected fat and hence the need for overcorrection and re-injection. The purpose of this study is to improve the viability of the injected fat by the use of Lipo-PGE1. METHODS: Human adipose tissue, obtained by suction-assisted lipectomy, was re-injected into the subcutaneous layer in the scalp of ICR mice. Lipo-PGE1 (0.5 microgram/kg) was injected intravenously in experimental group for 7 days from the operation day and saline was injected in control group. There were 5 animals in each group. The animals were euthanized 4 weeks after the procedure. Graft weight and volume were measured and histologic evaluation was performed. RESULTS: Histologic analysis demonstrated significantly less cyst formation and less inflammatory reaction in the group treated with Lipo-PGE1. No significant difference was found between the groups regarding graft volume or the other histologic parameters investigated. Significant differences were demonstrated in microvascular density count. CONCLUSION: Less cyst formation, less inflammation, more angiogenesis indicating improved quality of the injected fat can be obtained by the addition of Lipo-PGE1. Further studies of various dosages of Lipo-PGE1 and their long-term effect are required before these encouraging results could be applied clinically | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 526~530 | - |
dc.relation.isPartOf | Journal of the Korean Society of Plastic and Reconstructive Surgery (대한성형외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Lipo-PGE1이 이식된 지방 생존에 미치는 영향 | - |
dc.title.alternative | The effect of Lipo-PGE1 on the viability of injected adipose tissue on mouse model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Plastic Surgery & Reconstructive Surgery (성형외과학) | - |
dc.contributor.googleauthor | 오의선 | - |
dc.contributor.googleauthor | 정지은 | - |
dc.contributor.googleauthor | 유대현 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02459 | - |
dc.relation.journalcode | J01887 | - |
dc.contributor.alternativeName | Lew, Dae Hyun | - |
dc.contributor.affiliatedAuthor | Lew, Dae Hyun | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 526 | - |
dc.citation.endPage | 530 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Plastic and Reconstructive Surgery (대한성형외과학회지), Vol.37(5) : 526-530, 2010 | - |
dc.identifier.rimsid | 57291 | - |
dc.type.rims | ART | - |
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