Cited 6 times in
Increased γ-glutamyltransferase and decreased total bilirubin are associated with metabolic syndrome in Korean postmenopausal women
DC Field | Value | Language |
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dc.contributor.author | 이지원 | - |
dc.date.accessioned | 2015-04-23T17:23:56Z | - |
dc.date.available | 2015-04-23T17:23:56Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1434-6621 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102387 | - |
dc.description.abstract | BACKGROUND: The objective of this study was to determine if there is an association between serum hepatic markers and the metabolic syndrome in postmenopausal women. METHODS: This study involved 1229 postmenopausal women aged 44-85 years, who visited the Center for Health Promotion for a health check-up. We excluded subjects from the analysis if they had a daily alcohol consumption of more than 1.5 drinks (alcohol consumption ≥20 g/day) or had chronic viral hepatitis. We also excluded subjects who had abnormal hepatic function, as defined by serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >100 IU/L, serum γ-glutamyltransferase (GGT) >100 IU/L, or serum total bilirubin concentrations >2 mg/dL. RESULTS: Serum ALT and GGT concentrations increased in proportion to the number of elements of the metabolic syndrome (p<0.01). However, total bilirubin concentrations decreased (p=0.01). After adjusting for age, body mass index, and the presence of fatty liver in the patients with metabolic syndrome, the odds ratios (95% confidence interval) were 1.38 (0.89-2.15) for log (ALT), 1.69 (1.30-2.20) for log (GGT), and 0.53 (0.33-0.86) for log (total bilirubin). CONCLUSIONS: We found that an increase in GGT and a decrease in total bilirubin was associated with metabolic syndrome in postmenopausal women. Hepatic enzymes could be proposed as simple clinical metabolic markers that identify the metabolic syndrome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1623~1628 | - |
dc.relation.isPartOf | CLINICAL CHEMISTRY AND LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Bilirubin/blood* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver/enzymology | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Metabolic Syndrome/blood* | - |
dc.subject.MESH | Metabolic Syndrome/enzymology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postmenopause/blood* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | gamma-Glutamyltransferase/blood* | - |
dc.title | Increased γ-glutamyltransferase and decreased total bilirubin are associated with metabolic syndrome in Korean postmenopausal women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Sang-Hwan Kim | - |
dc.contributor.googleauthor | Ji-Won Lee | - |
dc.contributor.googleauthor | Jee-Aee Im | - |
dc.contributor.googleauthor | Hee-Jin Hwang | - |
dc.identifier.doi | 10.1515/CCLM.2010.302 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03203 | - |
dc.relation.journalcode | J00567 | - |
dc.identifier.eissn | 1437-4331 | - |
dc.identifier.pmid | 20704533 | - |
dc.identifier.url | http://www.degruyter.com/view/j/cclm.2010.48.issue-11/cclm.2010.302/cclm.2010.302.xml | - |
dc.subject.keyword | alanine aminotransferase | - |
dc.subject.keyword | γ-glutamyltransferase | - |
dc.subject.keyword | metabolic syndrome | - |
dc.subject.keyword | total bilirubin | - |
dc.contributor.alternativeName | Lee, Ji Won | - |
dc.contributor.affiliatedAuthor | Lee, Ji Won | - |
dc.citation.volume | 48 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1623 | - |
dc.citation.endPage | 1628 | - |
dc.identifier.bibliographicCitation | CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol.48(11) : 1623-1628, 2010 | - |
dc.identifier.rimsid | 57290 | - |
dc.type.rims | ART | - |
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