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Impaired finger dexterity in patients with parkinson's disease correlates with discriminative cutaneous sensory dysfunction

Authors
 Myung Sik Lee  ;  Chul Hyoung Lyoo  ;  Myung Jun Lee  ;  Jaeeun Sim  ;  Hanna Cho  ;  Yun Ho Choi 
Citation
 MOVEMENT DISORDERS, Vol.25(15) : 2531-2535, 2010 
Journal Title
 MOVEMENT DISORDERS 
ISSN
 0885-3185 
Issue Date
2010
MeSH
Aged ; Discrimination (Psychology)* ; Female ; Fingers/physiopathology* ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/physiopathology* ; Perceptual Disorders/complications ; Perceptual Disorders/physiopathology* ; Psychomotor Performance/physiology ; Regression Analysis ; Severity of Illness Index ; Touch Perception/physiology*
Keywords
Parkinson's disease ; finger dexterity ; discriminative cutaneous sense
Abstract
To study the influence of discriminative cutaneous sensory dysfunction on impaired finger dexterity in Parkinson's disease (PD), we evaluated 48 right-handed PD patients during a practically defined off-medication period and 24 healthy age-matched controls. With visual deprivation, a finger tapping task (FTT) was performed to assess the speed of simple repetitive finger movements and a coin rotation task (CRT) was used to assess finger dexterity. The tasks were performed with the right hand. We measured the somesthetic temporal discrimination threshold (sTDT) in the right index finger. The mean ± SD FTT score of the patient group was lower than that of the control group (24.0 ± 8.0 vs. 29.8 ± 7.8; P < 0.01). The patient group performed worse on the CRT than the control group (8.5 ± 3.5 vs. 12.6 ± 1.7; P < 0.001). The mean sTDT value of the patient group was longer than that of the control group (124.0 ± 44.8 vs. 78.1 ± 26.2 ms; P < 0.001). The CRT scores correlated with the sTDT values (Pearson's correlation coefficient = -0.43; P < 0.01), but not with the Unified Parkinson's Disease Rating Scale (UPDRS) finger bradykinesia scores or FTT scores. Multiple regression analysis showed that the sTDT values (parameter estimate = -0.03, SE = 0.01; P < 0.01), but not patient age, UPDRS finger bradykinesia score, or FTT score, affected the CRT score. Slowness of simple repetitive finger movements did not have a strong impact on the impaired manual dexterity of PD. Discriminative sensory dysfunction and consequent abnormal sensorimotor integration seem to be involved in the impaired finger dexterity of PD.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mds.23304/abstract
DOI
10.1002/mds.23304
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102376
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