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Surgical Outcomes and Prognostic Factors after Epilepsy Surgery in Children with Extratemporal Lobe Epilepsy

Other Titles
 측두염외 간질 소아 환자의 간질 수술 후 결과 및 예후 인자 
Authors
 Kum Ok Choi  ;  Hoon-Chul Kang  ;  PH.D.  ;  Joon Soo Lee  ;  Dong Seok Kim  ;  Heung Dong Kim 
Citation
 Journal of the Korean Child Neurology Society (대한소아신경학회지), Vol.18(1) : 20-32, 2010 
Journal Title
 Journal of the Korean Child Neurology Society (대한소아신경학회지) 
ISSN
 1226-6884 
Issue Date
2010
Keywords
Epilepsy ; Surgery ; Child ; Outcome assessment ; Prognosis
Abstract
PURPOSE: In this study, we reviewed surgical outcomes in children with extratemporal lobe epilepsy in our institution and suggested prognostic factors from these results. METHODS: We retrospectively analyzed the records of 59 patients(males n=35, females n=24; mean age of 10 years, mean age of seizure onset of 3 years, mean age of epilepsy surgery of 8 years) who received extratemporal lobe surgery between October 2003 to May 2008. Every patients were performed preoperative evaluation to determine the anatomical location of the ictal onset zone employing video electroencephalography(EEG) monitoring, intraoperative electrocorticography, intracranial EEG monitoring and neuroimagings such as Magnetic Resonance Imaging (MRI), positron emission tomography, interictal/ictal single photon emission computed tomography. Developmental test was taken at pre- and post-operation. RESULTS: Postoperative outcome as defined by Engel's classification were as follows; class I in 42(71.2%), II in 6(10.2%), III in 4(6.8%), and IV in 7(11.9%) patients. We considered six favorable prognostic factors from our data; age at operation, matching accuracy of video-EEG monitoring results, presence of a structural lesion on MRI, using specialized neuromodalities, involvement of lobe at surgery, and nature of the epileptogenic lesion. We also focused on unfavorable prognostic factors; no structural lesion on MRI, low grade of surgical pathology, postoperative epileptiform discharges on EEG. CONCLUSION: Early surgical intervention in pediatric patients with medically refractory seizure who possess focal epileptogenic foci of extratemporal lobe origin has been an effective and safe treatment
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Dong Seok(김동석)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
Choi, Keom Ok(최금옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102335
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