Cited 23 times in
The transcription factor snail regulates osteogenic differentiation by repressing Runx2 expression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박수진 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 최한석 | - |
dc.contributor.author | 가디죠게스 | - |
dc.date.accessioned | 2015-04-23T17:13:14Z | - |
dc.date.available | 2015-04-23T17:13:14Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 8756-3282 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102050 | - |
dc.description.abstract | Osteoblasts originate from mesenchymal stem cells by the coordinated activities of different signaling pathways that regulate the expression of osteoblast-specific genes. Runt-related transcription factor 2 (Runx2) is the master transcription factor for osteoblast differentiation. Despite the importance of Runx2 in the developing skeleton, how Runx2 expression is regulated remains a pivotal question. Snail, a zinc finger transcription factor, is essential for triggering epithelial-to-mesenchymal transitions (EMTs) during embryonic development and tumor progression. Here, we report that Runx2 expression is significantly up- or down-regulated relative to Snail expression. We demonstrate that Snail binds to the Runx2 promoter and that repression of Runx2 transcription by Snail is dependent on specific E-box sequence within the promoter. With antisense morpholino oligonucleotide (MO)-mediated knockdown of Snail expression in zebrafish, we observed alterations in osteogenic potential. These results indicate that Snail plays a crucial role in osteogenic differentiation by acting as a direct Runx2 repressor. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1498~1507 | - |
dc.relation.isPartOf | BONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Differentiation/genetics | - |
dc.subject.MESH | Cell Differentiation/physiology* | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Chromatin Immunoprecipitation | - |
dc.subject.MESH | Core Binding Factor Alpha 1 Subunit/genetics | - |
dc.subject.MESH | Core Binding Factor Alpha 1 Subunit/metabolism* | - |
dc.subject.MESH | Electrophoretic Mobility Shift Assay | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mutagenesis, Site-Directed | - |
dc.subject.MESH | Osteoblasts/cytology* | - |
dc.subject.MESH | Osteoblasts/metabolism* | - |
dc.subject.MESH | RNA Interference | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Snail Family Transcription Factors | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.title | The transcription factor snail regulates osteogenic differentiation by repressing Runx2 expression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Su Jin Park | - |
dc.contributor.googleauthor | Seung-Hyun Jung | - |
dc.contributor.googleauthor | Gadi Jogeswar | - |
dc.contributor.googleauthor | Hyun-Mo Ryoo | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Han Seok Choi | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Cheol-Hee Kim | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.identifier.doi | 10.1016/j.bone.2010.02.027 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02536 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A04206 | - |
dc.contributor.localId | A00001 | - |
dc.contributor.localId | A01540 | - |
dc.relation.journalcode | J00381 | - |
dc.identifier.eissn | 1873-2763 | - |
dc.identifier.pmid | 20215006 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S8756328210004874 | - |
dc.subject.keyword | Snail | - |
dc.subject.keyword | Runx2 | - |
dc.subject.keyword | E-box | - |
dc.subject.keyword | Osteogenic differentiation | - |
dc.contributor.alternativeName | Park, Su Jin | - |
dc.contributor.alternativeName | Yook, Jong In | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Choi, Han Seok | - |
dc.contributor.alternativeName | Gadi, Jogeswar | - |
dc.contributor.affiliatedAuthor | Yook, Jong In | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Choi, Han Seok | - |
dc.contributor.affiliatedAuthor | Gadi, Jogeswar | - |
dc.contributor.affiliatedAuthor | Park, Su Jin | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1498 | - |
dc.citation.endPage | 1507 | - |
dc.identifier.bibliographicCitation | BONE, Vol.46(6) : 1498-1507, 2010 | - |
dc.identifier.rimsid | 52687 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.