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Prevalence and seroprevalence of high-risk human papillomavirus infection

Authors
 Min-A Kim  ;  Jin-Kyoung Oh  ;  Doo Byung Chay  ;  Dong Choon Park  ;  Seok Mo Kim  ;  Eun-Suk Kang  ;  Jae-Hoon Kim  ;  Chi-Heum Cho  ;  Hai-Rim Shin  ;  Kyung Seo 
Citation
 OBSTETRICS AND GYNECOLOGY, Vol.116(4) : 932-940, 2010 
Journal Title
OBSTETRICS AND GYNECOLOGY
ISSN
 0029-7844 
Issue Date
2010
MeSH
Adolescent ; Adult ; Age Distribution ; Child ; Confidence Intervals ; DNA, Viral/analysis ; Female ; Human papillomavirus 16* ; Human papillomavirus 18* ; Humans ; Korea ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Papillomavirus Infections/epidemiology* ; Prevalence ; Seroepidemiologic Studies ; Young Adult
Abstract
OBJECTIVE: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women.

METHODS: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique.

RESULTS: The prevalence of genital high-risk HPV was 12.6% among Korean women aged 20-59 years. It reached a peak of 23.2% at 20-29 years of age, decreasing thereafter but increasing again to 12.4% at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7% among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4% at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9% at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4% and 2.7%, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners.

CONCLUSION: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy.

LEVEL OF EVIDENCE: III.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006250-201010000-00020&LSLINK=80&D=ovft
DOI
10.1097/AOG.0b013e3181edbeba
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Seo, Kyung(서경)
Chay, Doo Byung(채두병) ORCID logo https://orcid.org/0000-0002-0648-4021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102041
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