Inclusion body myositis ; Sporadic inclusion body ; myositis ; Idiopathic inflammatory
myositis ; Muscle biopsy
Abstract
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myositis in patients over
the age of 50 years. Prevalence of IBM varies among countries and ethnic groups. Etiology and
pathogenesis of IBM is still unknown. It may be primary degenerative myopathy or autoimmune
inflammatory myopathy or both. Asymmetrical weakness of the quadriceps and flexor forearm
muscles are the clinical key of IBM. This review covers clinical presentation, pathogenesis, diagnosis
and treatment of IBM.