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Belotecan for relapsing small-cell lung cancer patients initially treated with an irinotecan-containing chemotherapy: a phase II trial

 Jaeheon Jeong  ;  Byoung Chul Cho  ;  Joo Hyuk Sohn  ;  Hye Jin Choi  ;  Se Hyun Kim  ;  Young Joo Lee  ;  Min Kyu Jung  ;  Sang Joon Shin  ;  Moo-Suk Park  ;  Se Kyu Kim  ;  Joon Chang  ;  Joo Hang Kim 
 Lung Cancer, Vol.70(1) : 77-81, 2010 
Journal Title
 Lung Cancer 
Issue Date
BACKGROUND: Belotecan is a topoisomerase I inhibitor. This phase II trial was conducted to evaluate the efficacy and toxicity of belotecan in relapsing small-cell lung cancer (SCLC) patients after irinotecan failure. PATIENTS AND METHODS: SCLC patients, who had relapsed at least 3 months after achieving objective response to irinotecan plus platinum chemotherapy, were eligible. Belotecan was administered at a dose of 0.5 mg/m(2)/day for 5 consecutive days every 3 weeks. RESULTS: Twenty-seven patients were enrolled in this study. Twenty-five patients were evaluated for response, and 27 patients were evaluated for toxicity and survival. The overall response rate was 22%. The median time to progression was 4.7 months (95% CI, 3.6-5.8 months), and the median overall survival was 13.1 months (95% CI, 10.4-15.8 months). The most frequent grade 3/4 toxicities were neutropenia (93%) and thrombocytopenia (48%). There was one treatment-related death due to pneumonia. CONCLUSION: Belotecan showed modest activity and manageable toxicities in relapsing SCLC patients in this study which was conducted in Asia. But further study in Caucasian patients is needed.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김세규(Kim, Se Kyu)
김세현(Kim, Se Hyun)
김주항(Kim, Joo Hang)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
손주혁(Sohn, Joo Hyuk) ORCID logo https://orcid.org/0000-0002-2303-2764
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
정민규(Jung, Min Kyu) ORCID logo https://orcid.org/0000-0001-8281-3387
정재헌(Jung, Jae Hun)
조병철(Cho, Byoung Chul) ORCID logo https://orcid.org/0000-0002-5562-270X
최혜진(Choi, Hye Jin) ORCID logo https://orcid.org/0000-0001-5917-1400
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