Cited 22 times in
Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-04-23T17:10:07Z | - |
dc.date.available | 2015-04-23T17:10:07Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101950 | - |
dc.description.abstract | BACKGROUND: We have previously reported that TNF-α levels correlate to total mycobacterial burden in tuberculosis (TB) patients. OBJECTIVE: To characterize the dynamics of cytokine responses in TB patients during chemotherapy to identify potential surrogate markers for effective treatment. METHODS: Following induction by culture filtrate proteins in whole blood, production patterns of TNF-α, IL-10, IFN-γ and IL-12 were measured in 23 non-multidrug-resistant (MDR)-TB and 16 MDR-TB patients and in 31 healthy controls. Rates of mycobacterial clearance from the sputum were then measured and compared. RESULTS: Prior to the initiation of chemotherapy, TNF-α and IL-10 levels were significantly higher in TB patients than in healthy controls while IFN-γ and IL-12 levels were similar. During chemotherapy, the levels of all 4 cytokines increased. We evaluated these responses separately in patients that did and did not clear their sputum culture at 2 and 6 months. At 2 months, decreases in both IFN-γ and IL-12 correlated strongly with a successful early response, while after 6 months of therapy, when half (7/14) of MDR-TB patients were still sputum culture positive, downregulation of TNF-α was uniquely correlated with sputum conversion between the groups. CONCLUSION: Our findings suggest the possibility that the regulation of TNF-α production in whole blood may be a more specific indicator of sputum conversion at 6 months than IFN-γ, IL-12 or IL-10 in MDR-TB patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 275~284 | - |
dc.relation.isPartOf | RESPIRATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antitubercular Agents/therapeutic use* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/blood | - |
dc.subject.MESH | Interleukin-10/blood | - |
dc.subject.MESH | Interleukin-12/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium tuberculosis/isolation & purification* | - |
dc.subject.MESH | Sputum/microbiology* | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/blood* | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/drug therapy | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/blood* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology & Immunology (미생물학) | - |
dc.contributor.googleauthor | Seok-Yong Eum | - |
dc.contributor.googleauthor | Ye-Jin Lee | - |
dc.contributor.googleauthor | Jin-Hong Min | - |
dc.contributor.googleauthor | Hyun-Kyung Kwak | - |
dc.contributor.googleauthor | Min-Sun Hong | - |
dc.contributor.googleauthor | Ji-Hye Kong | - |
dc.contributor.googleauthor | Soo-Hee Hwang | - |
dc.contributor.googleauthor | Seung-Kyu Park | - |
dc.contributor.googleauthor | Jason J. LeBlanc | - |
dc.contributor.googleauthor | Laura E. Via | - |
dc.contributor.googleauthor | Clifton E. Barry | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.identifier.doi | 10.1159/000283687 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J02613 | - |
dc.identifier.eissn | 1423-0356 | - |
dc.identifier.pmid | 20145387 | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | Interferon-γ | - |
dc.subject.keyword | Interleukin-10 | - |
dc.subject.keyword | Interleukin-12 | - |
dc.subject.keyword | Multidrug-resistant tuberculosis | - |
dc.subject.keyword | Mycobacterial clearance | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Tumor necrosis factor-α | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.citation.volume | 80 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 275 | - |
dc.citation.endPage | 284 | - |
dc.identifier.bibliographicCitation | RESPIRATION, Vol.80(4) : 275-284, 2010 | - |
dc.identifier.rimsid | 50968 | - |
dc.type.rims | ART | - |
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