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1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis

DC FieldValueLanguage
dc.contributor.author서경률-
dc.date.accessioned2015-04-23T17:07:32Z-
dc.date.available2015-04-23T17:07:32Z-
dc.date.issued2010-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101868-
dc.description.abstractBACKGROUND: Vitamin D(3), the most physiologically relevant form of vitamin D, is an essential organic compound that has been shown to have a crucial effect on the immune responses. Vitamin D(3) ameliorates the onset of the experimental autoimmune encephalomyelitis (EAE); however, the direct effect of vitamin D(3) on T cells is largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: In an in vitro system using cells from mice, the active form of vitamin D(3) (1,25-dihydroxyvitamin D(3)) suppresses both interleukin (IL)-17-producing T cells (T(H)17) and regulatory T cells (Treg) differentiation via a vitamin D receptor signal. The ability of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) to reduce the amount of IL-2 regulates the generation of Treg cells, but not T(H)17 cells. Under T(H)17-polarizing conditions, 1,25(OH)(2)D(3) helps to increase the numbers of IL-10-producing T cells, but 1,25(OH)(2)D(3)'s negative regulation of T(H)17 development is still defined in the IL-10(-/-) T cells. Although the STAT1 signal reciprocally affects the secretion of IL-10 and IL-17, 1,25(OH)(2)D(3) inhibits IL-17 production in STAT1(-/-) T cells. Most interestingly, 1,25(OH)(2)D(3) negatively regulates CCR6 expression which might be essential for T(H)17 cells to enter the central nervous system and initiate EAE. CONCLUSIONS/SIGNIFICANCE: Our present results in an experimental murine model suggest that 1,25(OH)(2)D(3) can directly regulate T cell differentiation and could be applied in preventive and therapeutic strategies for T(H)17-mediated autoimmune diseases.-
dc.description.statementOfResponsibilityopen-
dc.format.extente12925-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCalcitriol/administration & dosage*-
dc.subject.MESHCell Differentiation/drug effects*-
dc.subject.MESHCell Movement/drug effects-
dc.subject.MESHDown-Regulation*-
dc.subject.MESHEncephalomyelitis, Autoimmune, Experimental/drug therapy*-
dc.subject.MESHEncephalomyelitis, Autoimmune, Experimental/immunology-
dc.subject.MESHEncephalomyelitis, Autoimmune, Experimental/physiopathology-
dc.subject.MESHEncephalomyelitis, Autoimmune, Experimental/prevention & control-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-2/immunology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMultiple Sclerosis/drug therapy*-
dc.subject.MESHMultiple Sclerosis/immunology-
dc.subject.MESHMultiple Sclerosis/physiopathology-
dc.subject.MESHMultiple Sclerosis/prevention & control-
dc.subject.MESHProtective Agents/administration & dosage*-
dc.subject.MESHTh17 Cells/cytology*-
dc.subject.MESHTh17 Cells/drug effects-
dc.subject.MESHTh17 Cells/immunology-
dc.title1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorJae-Hoon Chang-
dc.contributor.googleauthorHye-Ran Cha-
dc.contributor.googleauthorDong-Sup Lee-
dc.contributor.googleauthorKyoung Yul Seo-
dc.contributor.googleauthorMi-Na Kweon-
dc.identifier.doi10.1371/journal.pone.0012925-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01870-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid20886077-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.citation.volume5-
dc.citation.number9-
dc.citation.startPagee12925-
dc.identifier.bibliographicCitationPLOS ONE, Vol.5(9) : e12925, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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